Foreword

In many ways, nutrition has been a lost frontier in achieving optimal health. Only relatively recently—and outside of some early adopters—has the role of nutrition been appreciated in athletic performance, healthy aging, degenerative diseases, and most importantly maintaining health for as long as possible. To further understand, fine-tune, and improve the positive role nutrition plays in optimal health, a significant innovation in nutrition must occur.

When it comes to the field of nutrition, there are a few areas that are ripe for innovation. However, before we get into innovation in nutrition let’s start with a brief history of nutrition to help understand how we got to where we are today.

Essential micronutrients and macronutrients

In talking about essential nutrients, we are talking about the compounds we must get through our diet or nutritional supplement to sustain life. These nutrients are essential because our bodies do not make them. There are two general categories of essential nutrients: 1) essential macronutrients and 2) essential micronutrients.

Macronutrients are the nutrients we need in larger quantities (usually >1 gram). These are the raw materials our cells need to 1) build the structures that make up our bodies and 2) burn for energy—fats, proteins, and carbohydrates.

Essential micronutrients are the minerals and vitamins our bodies need but in smaller quantities (usually <1 gram). Some minerals, like calcium, for example, could be considered macronutrients because we need them in large dosages. However, because we cannot burn calcium and other minerals for energy, most nutritionists lump them into the “micronutrient category.” Simply put, essential minerals are the inorganic substances our bodies need to support life, and the essential vitamins are the organic compounds our bodies need to support life.

It has long been appreciated that we must eat food (macronutrients) to survive. It has also long been appreciated, mostly from early physicians, that minerals are important because of the composition of bone. However, the role essential vitamins played in health remained much more elusive. It is the luxury of 21^st century hindsight that makes the discovery of essential vitamins so interesting. Therefore, vitamins will be the main focus of this brief historical perspective.

Discovery of essential vitamins

Although they didn’t know it at the time, it was the earliest seafaring explorers who were responsible for the discovery of vitamins. On their long voyages, sailors would almost exclusively eat dehydrated foods and fish with little or no fresh fruit or vegetables. This diet put sailors at risk for vitamin C deficiency and scurvy. The severe symptoms of scurvy (general weakness, tooth loss, blood spots, excessive bruising, etc.) would appear as soon as 10 to 12 weeks into a voyage—the first observable and documented disease of nutritional deficiency. However, it was also observed that as soon as sailors reached land and began consuming “acid fruits,” their symptoms would disappear in as little as one to two weeks. The British navy was the first to appreciate this observation and adopted the use of citrus juice (mostly lemon or lime juice) into the sailors’ daily rations—all but curing this disease in its sailors. The exact reason and specific compound(s) responsible for the amelioration of scurvy would evade discovery until the early 1930s when a Hungarian researcher, Albert Szent-Györgyi, discovered vitamin C—literally hundreds of years later.

Again, with the luxury of hindsight in modern science and medicine, it is clear why scurvy was the primary concern of these early explorers. Vitamin C is highly water-soluble. We have a relatively high daily requirement because we are one of the few animals that does not synthesize vitamin C. And the fact that we are poor at recycling it means that vitamin C is usually the first nutrient depleted from our bodies. Thus, scurvy is one of the first diseases of nutrient deficiency to manifest overt symptoms.

Fast forward to the 1800s when widespread European colonization of Asia, Caribbean, and Pacific Islands was occurring, and many other diseases of nutrient deficiency began to be observed. It was only when the observations of different European physicians were lumped together that the role of nutrition in preventing diseases of nutritional deficiency became clear. Basically, sailors, soldiers, prisoners, and even farm animals fed homogeneous, restricted, and/or limited diets became at risk for “disease.” However, proving exactly what caused these diseases proved to be elusive. Further compounding the discovery of essential vitamins was timing. Research into diseases of nutritional deficiency was occurring at the height of the “Pasteurian revolution”—or “germ theory of disease”—a time when microscopic organisms were thought to be the cause of all maladies. This led researchers down many experimental dead-ends.

It wasn’t until the 1890s that a Dutch physician working with chickens discovered the difference between a chicken (or soldier) developing the “neurological disease” known as beriberi was whether they were fed “brown” or “white” rice. This discovery was ultimately responsible in solidifying the notion that “components of food” could be responsible for health or disease. This sparked a scientific revolution into the 1900s that lasted up through 1941 when folic acid, the last discovered essential vitamin, was described.

Establishment of dietary guidelines

During the second World War, a time when global war and economic depression was occurring and food rationing and starvation were rampant, the United States determined it needed to set nutritional guidelines. No doubt to gain an upper hand in the war effort, the United States National Defense Advisory Commission mandated the United States National Academy of Sciences establish the United States National Research Council to investigate the role nutrition might have in national defense. The goal was to maintain a healthy fighting force and civilian population, and help guide overseas relief efforts. In 1941, the first Recommended Daily Allowances, or RDAs, were put into practice. While these dietary guidelines were initially established by the United States, many countries around the world have either adopted these guidelines outright or have some modified version thereof. The RDAs (or the now broader dietary guidelines known as the Dietary Reference Intakes) are only updated on average, every five to 10 years. As such, since their inception, these dietary recommendations have only been updated a handful of times and leaves us where we are today.

Governmental regulations preventing diseases of nutritional deficiency versus optimal health

The common denominator of how essential vitamins were discovered and how governmental guidelines were established was “preventing diseases of nutritional deficiency and other complications of malnutrition”. Thus, these governmental regulations, guidelines, and recommendations have never been considered dosages to achieve “optimal health”. For regulatory agencies to ultimately modify their recommendations from “minimal amounts” of nutrients to stave off diseases of nutritional deficiency to “optimal amounts” of nutrients to promote health, significant investment and novel experimental approaches in the nutritional sciences must occur. For the general public to benefit from this science it must be accessible, understandable, and ultimately simple, personalized nutritional recommendations made. To marry these seemingly distinct goals, a significant innovation in nutrition must occur.

Innovation in Nutrition

Increased nutritional research

Our bodies and cells work because of biochemical reactions occurring within them. For these chemical reactions to work and to work as efficiently as possible, they need a number of nutrients and cofactors—in the right concentration, balance, and form—to function optimally. To date, there has been a severe drought of basic nutritional research in determining what exactly are “optimal levels” of nutrients we as individuals should be striving to consume daily. For example, what are optimized levels of nutrients to maximize athletic performance and let us age healthily? And most importantly, what levels of nutrients do we need to consume daily as an individual to maintain health for as long as possible—our so-called “healthspan”?

This gap in the scientific literature is likely due to two major factors. First, is a general lack of funding for nutritional research, both from governmental agencies and the private sector. The lack of funding from many major governmental agencies is likely multifactorial and complicated, but whatever the reason, there simply has not been the dedication to funding nutritional research relative to other areas of study. In regards to the private sector, large-scale, long-term human clinical trials are very expensive. These clinical studies can cost millions of dollars per year to run. And because many of these studies would need to be run for five, 10, 15, 20, or more years, they simply become cost prohibitive for even the largest of corporations to fund solely out of revenues.

Second, many scientists have recently called into question whether the traditional scientific model of “randomized, placebo-controlled trials” (so-called RCTs) are the right method to conduct nutritional clinical studies. These RCTs work well in the pharmaceutical industry because the molecules they are experimentally testing are almost never found naturally within our bodies. Because many governments prohibit patenting natural compounds, the pharmaceutical industry must develop synthetic molecules to patent-protect their research investments. This makes pharmaceutical experimental methods much more straightforward and much easier to determine a direct cause-and-effect. Their potential new drug is either found in us or not; their potential new drug either has an effect or not. Because of this literal binary methodology, these studies are much more cost effective and direct conclusions easier to draw.

This is not the case with nutrition. When similar clinical studies are performed in humans, we will all have some baseline level of nutrients in our bodies simply because of the food we eat. Further compounding this fact, based on the specific diet each of us is eating, some of us will have relatively high levels of some nutrients, and others relatively low levels. This fact is almost never considered when designing nutritional studies. Taken together, nutritional experimental methods become much less straightforward. These differing baseline levels increase experimental error. Because experimental error can become high this makes determining a direct cause-and-effect of nutritional interventions on a specific health outcome much more difficult to conclude. Without proper experimental design, having massive numbers of test subjects, and proper statistical analyses, this core difference in pharmaceutical and nutritional research often explains many of the equivocal results published in the scientific literature.

Further compounding experimental design and the interpretation of results is that nutrients don’t work in isolation in any single biochemical/metabolic pathway. Within every given metabolic pathway within our cells, there will be a number of nutrients and cofactors facilitating the biochemical/metabolic reactions. Thus, experimentally testing one nutrient in the context of all the other nutrients needed in a metabolic pathway and measuring a health improvement is hopeful at best. Based on nutritional and biochemical/metabolic science, best practices would include experimentally administering all nutrients in a given biochemical/metabolic pathway where a specific health outcome is desired. This, however, goes against the hundreds-of-years-old “scientific method” every scientist is taught.

The scientific method states that only one experimental variable can be changed relative to the control or placebo group. In literally every case of nutrition as it relates to health and disease, this is simply a flawed approach. Proper nutritional and biochemical/metabolic practices would demand all known nutrients in a given metabolic pathway be experimentally administered to expect a health improvement. However, this practice not only goes against the scientific method but also compounds a clear cause-and-effect interpretation of results. While this fact is appreciated by many nutritional and biochemical/metabolic scientists, when applying for governmental research monies, any experimental design outside of the scientific method is generally considered “poorly designed” and often fails to receive funding.

Simply put, for significant innovation in nutrition to occur, there needs to be a renaissance in basic nutritional science. For that to happen, a dogma change in traditional nutritional experimental design has to occur. New experimental paradigms will also need to be developed to answer nutritional experimental questions. And this is exactly what some forward-thinking nutritional and biochemical/metabolic scientists are doing—looking for methodologies outside of the traditional scientific method to answer nutritional research questions. These scientists are taking a non-hypothesis driven, non-targeted approach to nutritional science. That is, giving many nutritional interventions simultaneously relative to a control group, measuring numerous biochemical and metabolic outcomes, and then reconstructing the data based on known biochemical and metabolic principles. While this is a costly, complicated, and time-consuming approach it is allowing these scientists to make strong relationships between multiple nutritional interventions and their effects on biochemical and metabolic pathways. In other words, they are letting the data tell the story and not forcing data into preconceived or biased hypotheses because of flawed experimental design. This is likely the approach nutritional scientists will need to take in the future.

Ultimately, increased research funding, a renewed resurgence and commitment to basic nutritional research, and improved and novel experimental designs constitutes a great innovation in nutritional science.

Conditionally essential and non-essential nutrients and cofactors

We clearly need essential nutrients to survive and be healthy. But a new aspect of nutrition that is increasingly being appreciated is what is known as “conditionally essential” nutrients. As mentioned above, the last essential vitamin (folic acid) was discovered in 1941. And while there have been some potential candidates of yet undiscovered essential nutrients such as pyrroloquinoline quinone (PQQ for short), ergothioneine, and others, the likelihood of finding another absolute essential vitamin is unlikely. However, what is likely to occur through increased nutritional research is the characterization of more and more conditionally essential nutrients and cofactors, including essential vitamins and minerals.

What are “conditionally essential nutrients and cofactors?” Unlike essential nutrients directly linked to diseases of nutritional deficiency, there is no direct link between conditionally essential nutrients and cofactors and diseases of nutritional deficiency. However, what we are talking about are potential sub-clinical deficiencies were no overt signs of disease are present but where metabolism and cellular function are compromised.

A nutrient or cofactor might become conditionally essential during different stages of our lives. For example, we know that as we get older our bodies don’t absorb minerals and some vitamins as efficiently as in our youth. Additionally, it has been shown that non-essential nutrients and cofactors such as lipoic acid and carnitine decrease with age. We know that many elite athletes and women of childbearing age tend to need more iron and many other nutrients to maximize oxygen carrying capacity and support the additional stresses of athletics and child rearing. We know that following an acute physical injury, vitamin D levels crash. We know that we put on the majority of our life-long bone mass before the age of 20 and so pound-for-pound (or kilo-for-kilo), children need more bone minerals than adults.

A better understanding of candidate nutrients and cofactors that may not be “essential” by the strict nutritional definition but that may lead to a subclinical and compromised cellular, tissue, or organ function is needed. Or alternatively, describing conditionally essential nutrients and cofactors that would deliver additional health benefits through increased levels of supplementation. Expanding research into characterizing conditionally essential nutrients and cofactors to better determine the exact dosages needed, at specific periods of time in the lifespan, would be a great innovation in nutrition.

Personalized nutrition

It has been proposed by some theoretical biologists that the odds of any one of us being born exactly like we are, at this specific point in time, and under these specific circumstances to be around 1:400,000,000,000 (yes, one out of 400 trillion). So by that definition, if there were 400 trillion people currently living on Earth, there might be someone who was exactly identical to you or me in every way. Since there are currently only seven billion people on Earth, the likelihood that any two of us are exactly identical is highly unlikely at best. Therefore, one could easily surmise that we all have individual, unique, and personalized nutritional requirements.

Historically speaking, governmental agencies have not taken this nuance into account. Many recommendations coming from various regulatory bodies have lumped all nutritional requirements into large, population-based groups. Only more recently have different “life stages” and nutritional requirements been appreciated: for example, how old we are, if we use tobacco, or if a woman is pregnant or breastfeeding.

To have useful innovation in nutrition, it will be paramount to understand what smaller and more defined populations’ specific nutritional needs are—and ultimately any given individual’s exact, specific nutritional requirements—to increase the efficacy of nutrition as it relates to promoting optimal health.

Cellular and molecular targeting of nutrients

It has long been appreciated that our cells contain extensive communication networks known as cell-signaling pathways. These cell-signaling pathways allow the cells to communicate what is happening within a single cell, to its neighboring cell, or to cells that may be long distances away.

The sole purpose of these cell-signaling pathways is to help a cell, tissue, or organ adapt and respond to its environment. How does this work? There are “sensor molecules” (usually proteins) that live both on the surface and inside all cells. Like a lock and key, when the right molecule (key) hits the right sensor (lock), you initiate a cell-signaling pathway and communication commences. Think of a chain of dominoes being knocked over. Once initiated, the cell signaling pathway will ultimately have a physiological effect on the cell, tissue, organ, or even the body’s entire physiology—either turning biological processes on or turning biological processes off.

Certain nutrients can work at the molecular level to target cell-signaling pathways and yield a health benefit. For example, the compounds found in dark chocolate or the seeds of grapes can help support cardiovascular health. Caffeine can mimic adrenaline and give us both heightened cognitive function and improved athletic performance. Certain nutrients from plants (phytonutrients) have been shown to activate our body’s own natural detoxification processes, while others act like non-steroidal, anti-inflammatories (so-called NSAIDS). This happens because nutrients are working at the molecular level to activate cell-signaling pathways. And nutritional scientists are now capitalizing on molecular targeting of natural compounds within a cell to elicit specific, healthful, and efficacious physiological effects.

Learning exactly which nutrients—and at what precise dosages—target specific cell-signaling pathways to yield health benefits is in its infancy, and it is ripe for innovation.

The “omics” revolution in nutrition

The so-called “omics revolution” has been trendy in science, especially the biological sciences. The phrase comes from the suffix of many subfields of biology such as genomics (the study of DNA), proteomics (the study of proteins and enzymes), microbiomics (the study of microorganisms that live in and on us) and metabolomics (the study of metabolism).

This “omics” trend is the result of a notion in biology known as “systems biology”—how all the individual systems are working within our bodies to make us who we are. This is taking a more computational or engineering approach to understanding biology: from looking at what is in our DNA and what it tells us about our propensity for a particular health outcome (genomics), to how our cells turn that DNA message into our cellular protein machinery (proteomics), to how all the mutualistic microorganisms that live in and on us interact with our environment and affect our physiology (microbiomics).

Systems biology’s promise was to look at the complex interplays within those systems to help us understand the complexity of biology. And while systems biology was meant to give us less of a reductionist approach to biology, it has failed to deliver fully on its promise. It turns out there are many systems within the cell, so studying a single system (genomics, proteomics, microbiomics, etc.) doesn’t give us the complete picture, much less the interplay among all of these individual systems. But if you believe that, biologically speaking, we are nothing more than a bag of biochemical reactions—and it is those biochemical reactions that make us who we are—there could be one “systems approach” that could give us tremendous insight and help us innovate in nutrition. That promise is metabolomics.

The promise of metabolomics

As mentioned above, metabolomics is the study of the biochemistry of our entire metabolism. The promise of metabolomics comes from the fact that it takes into account many, if not all, systems in systems biology. Hierarchically speaking, it is the one process that can take all potential variables into account, simultaneously, regardless of the DNA we inherited from our parents; regardless of how efficiently we turn that DNA into useful protein machinery for the cell; regardless of how our microbiome is affecting our physiology; and regardless of things we haven’t even talked about yet, such as how efficiently we absorb nutrients, our lifestyles, and the environment in which we live. All of these things directly or indirectly affect our cellular biochemical reactions, and metabolomics takes all of these—and more—into account.

The promise of metabolomics also comes from the fact that our specific cellular biochemistry has been known for a number of years; that is, literally, every metabolic pathway in our bodies has been mapped out—not just the major players and pathways, but also the minor pathways and “metabolites.” By having such well-defined cellular biochemistry that includes the biochemical reactants, the metabolic intermediates, and all the necessary enzymes, cofactors, vitamins, minerals, etc. needed to conduct this biochemistry, we can know if our metabolism is functioning optimally or might be perturbed. And because there are trillions of chemical reactions occurring at any given time within our body, we can literally get a minute-by-minute or even second-by-second snapshot of how our metabolism is running.

All that said, it is exactly this promise of metabolomics that has also been the very thing to hold it back. Many researchers have shied away from full-blown metabolomics because of its inherent complexity. To get a complete view of our “metabolome” (everything that makes up our metabolism), one would literally have to measure hundreds-of-thousands of metabolites, simultaneously, as often as possible, over a wide-range of scenarios, to get an accurate view. As you can imagine, that becomes exponentially complex very quickly.

But technology in this field is rapidly advancing. It is now possible to measure tens-of-thousands of metabolites experimentally with more being added literally every day. But this complexity would only exist in the initial basic metabolomics research. Once an accurate snapshot of the metabolome, over many lifestyle scenarios, was captured, it would be possible to utilize a few key metabolites to know exactly how our cells are functioning. And going back to nutrition, we could determine exactly what we needed to put in our bodies to keep those cells functioning as optimally as possible. What should I eat? Carbohydrates? Proteins? Fat? When? Am I nutrient deficient? What nutrients do I need? When? And at what dose? The level of granularity, specificity, and real-time feedback provided by metabolomics is its real promise.

Going back to our example of scurvy (the disease of vitamin C deficiency): the reason individuals’ teeth fall out, they bruise easily, and they usually die of a cardiovascular event (aneurysm or heart attack) is because vitamin C is required for collagen synthesis—the “molecular glue” that holds our cells and blood vessels together. In this example, utilizing metabolomics, if we could identify when collagen synthesis or some seemingly unrelated metabolite first begins to become compromised, we could intervene and recommend consuming vitamin C to get this metabolic pathway back on track. This metabolic compromise could be identified far before any clinical symptoms present themselves or even subclinical consequences would negatively affect the cell. And we could use similar examples for maximizing energy production, muscle synthesis, brain function, and markers of disease or health. Literally, every biological process could be optimized using metabolomics.

A better basic understanding of metabolomics and which key metabolites to use as markers of optimal nutritional status and health is the penultimate innovation in nutrition.

Medical devices, fitness trackers, breathalyzers, and optical scanners

There are currently a number of devices available on the market whereby consumers can measure a number of important health endpoints. In terms of currently accepted medical devices, they include instruments that measure blood pressure, pulse wave velocity, weight, body composition, blood lipids, cholesterol, C-reactive protein, body temperature, and blood glucose, to name a few.

The popularity of fitness trackers has exploded to a global multi-billion dollar industry. Clearly, there is a demand for devices that give real-time feedback on health measurements. The most popular fitness trackers tell us how many steps we’ve walked, how far we’ve run, how efficient our swim stroke was, what our cycling cadence and power output is, heart rate, calories burned, and how well we have slept.

In more recent years, there’s been a resurgence of non-invasive technologies where specific wavelengths of light are shone into human tissue to determine health endpoints, such as blood oxygen saturation, pulse, macular pigment density, skin health, hydration, and even the status of certain nutrients, and antioxidants, with blood glucose being the “Holy Grail” of “Big Pharma.” You are also probably familiar with breathalyzers that can determine our blood alcohol content. There has also been a resurgence of breathalyzers (measuring metabolites in our breath) to determine metabolic health or even outright disease states.

Where this industry has left us short is being able to couple all of the aforementioned endpoints, and others, into a single device to give us a comprehensive look into our health status. Merging all of these endpoints and technologies into a single device that could measure our nutritional and health status in real-time would be a huge innovation in nutrition.

Coupling medical devices to nutritional, medical, and metabolomics data

The final innovation that needs to occur in nutrition is taking the comprehensive medical device referenced above and coupling it to the latest scientific discoveries in nutrition, medicine, and metabolomics. Imagine the possibilities if you could hold a medical device up to your finger; maybe give a small drop of blood or shine a light into it, or blow through a tube to get an overall snapshot of what your metabolism (metabolome) looks like in real-time. You could then take that information and receive a recommendation of a nutrient you might be low in, a food you should eat, or if you need to exercise. Such a device would ensure we keep our metabolism and biochemistry working as efficiently as possible and almost literally in real-time. We could maximize athletic performance, optimize our health, and most importantly, maintain our healthspan for as long as possible.

Coupling cutting-edge nutritional breakthroughs, especially in the field of metabolomics, with a comprehensive, non-invasive medical device to give us an instantaneous snapshot of our metabolic health, and hence our overall health, is the ultimate innovation in nutrition that will meaningfully affect human health.

Conclusion

The mid-1800s through the mid-1900s was the defining time in nutrition. Those 100 years set the tone for how we think about nutrition today—minimal amounts of nutrients treating diseases of nutritional deficiency. We need to change the current nutritional dogma from minimal amounts of nutrition to optimal levels of nutrition to promote optimal health. If meaningful innovation in nutrition is to occur, there must be a renewed emphasis and dedication to basic nutritional research, especially how nutrients work on the molecular level. New scientific methods applicable to nutrition must also be developed and accepted in the scientific community to take less of a reductionist approach to nutritional research and more of a systems—or engineering—approach. The systems approach that is the most promise in nutrition is metabolomics, and this is where the majority of nutritional research should occur. Applying novel, non-reductionists, untargeted, non-hypothesis driven research methodologies to metabolomics will create real innovation in nutrition. Once we achieve a relatively complete understanding of how nutrients both directly and indirectly affect our metabolism, can we couple this knowledge with existing medical devices and develop new ones. Together, this will turn basic research into usable and actionable information whereby any consumer can take deliberate action to ultimately increase their health span.

This is the promise of innovating in nutrition.

Get a Good Night’s Sleep with USANA® Pure Rest™ So You Can Rise and Shine

USANA® Pure Rest™

Give your body a boost of melatonin to help support your natural sleep-and-wake cycle.

Your life is full of demands. And showing up—physically, mentally, and emotionally—for whatever’s important in your day starts with getting enough sleep the night before. Not to mention that regularly getting 7-9 hours of sleep a night is essential for your overall health and well-being. If you sometimes need a little help drifting off at night, USANA® Pure Rest™ can help you get to sleep, so you can rise and shine the next morning.*

Pure Rest is a fast-acting melatonin supplement. It supports the body’s natural sleep-and-wake cycles by adding to your natural melatonin production at night. When taken at bedtime, Pure Rest supports the body’s natural circadian rhythms. They signal your body that it’s time to sleep. It’s especially helpful if your normal sleep schedule has been disturbed due to working odd hours or traveling and jet lag.* Pure Rest is not a sleeping pill. It’s non-habit forming. Simply take Pure Rest as part of your bedtime routine to help you get the sleep of your dreams every night.*

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Don’t Take a Lack of Sleep Lying Down

Sometimes, when life gets demanding, you just aren’t going to get enough sleep. And if you occasionally find yourself struggling to fall asleep, it’s time to take action.

Running on too few hours of sleep won’t just leave you tired, grumpy, and mentally foggy. Even one night of sleep deprivation may have mental and physical consequences for your daily well-being.

Unfortunately, if you’re in need of more pillow time, you’re not alone. Millions of people need more sleep. It’s become so common that it’s the new “normal.” But not getting enough sleep isn’t something you can relax about. It’s actually considered a growing, unmet health problem by the Institute of Medicine. And with good reason.

Sleep quality supports a number of aspects of health:

Restoring the body after daily stress and exposure to free radicals*
Immune function *
Tissue repair (including joints) and healthy muscle growth*
Fitness recovery*
Cardiovascular health*
Maintaining healthy blood glucose levels (as long as they’re already in the normal range)*
Appetite, dietary intake, and weight*
Normal cognitive function and mood*
Vision*
Skin appearance*

Getting enough quality sleep will not only help you feel energized and productive. It will also help undo some of the effects of daily wear and tear on your body and increase your odds of living a healthier life.*

The goal? The National Sleep Foundation suggests adults aim to regularly get 7-9 hours of sleep a night. This is based on a rigorous scientific review of studies that related sleep duration to health, performance, and safety. The panel of experts found that those who sleep, on average, less than six hours a night may experience greater impacts to their well-being than those who average seven to eight hours a night.*

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The Rhythm of the Night

Your sleep cycle is controlled by your internal biological clock, known as circadian rhythms. This 24-hour cycle regulates a number of bodily functions, including telling your body when it should be asleep and awake. Circadian rhythms are a natural process within your body, but they can be influenced by outside factors.

A number of things can disrupt your sleep cycle (or sleep quality):

Stress
Working night shifts
Traveling across time zones
Artificial lighting (including LED light bulbs and the blue light coming from your smart phone or other electronic devices)
Alcohol or drug consumption
Age (melatonin levels may naturally drop, and you’ll tend to experience more sleep disturbances)

Make regularly getting your ZZZ’s a priority. Daily exercise; limited use of electronic devices and light exposure before bed; and a comfortable, dark sleep environment can all help you get good quality sleep. You can also support a good snooze by giving your natural circadian rhythms added support with a boost of melatonin.

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Support Your Sleep to Sustain Your Health with USANA Pure Rest

Melatonin is the key to getting to sleep. This naturally occurring hormone is produced primarily in the pineal gland in your brain. Regulating normal sleep-and-wake cycles is melatonin’s main job. During the day, your body doesn’t make melatonin. Then levels naturally start to rise in the evening. Melatonin levels remain elevated for most of the night, signaling to your body that it is time to sleep.

To boost melatonin from plant-based sources, try adding tomatoes, olives, walnuts, or strawberries to your diet. Or, you can add tryptophan, which is an essential amino acid that your body uses to make melatonin. Tryptophan is found in eggs, poultry, dairy products, chickpeas, and almonds.

Get truly reliable levels of melatonin to help mimic the activity of your natural, sleep-inducing hormone with USANA Pure Rest. Each sugar-free, orange-flavored tablet contains 2 milligrams (mg) of pure melatonin from non-animal sources. And the tablet is scored, so you can easily break it in half to adjust the dosage to fit your needs.*

Taken about an hour before bedtime, Pure Rest will help your melatonin levels increase gradually. As melatonin levels rise, you will become less alert, feel drowsy, and eventually fall asleep. It’s a healthy way to support sleep without experiencing harsh side effects. But you’ll want to take Pure Rest at least five hours before you need to wake up, to help ensure you’ll feel refreshed and focused the next day.*

If you’re worried about a lack of sleep ruining your vacation or making you groggy on a business trip, Pure Rest should be your travel companion. It may help reduce jet-lag when traveling, especially if you’re headed east or across two or more time zones. A dose of approximately 5 mg has been shown to be most effective when crossing many time zones.*

To all you night owls: Supplementing your melatonin with Pure Rest could be especially important if you are exposed to artificial light at night, while it’s dark outside. Light exposure can upset your circadian rhythms and suppress the natural release of melatonin. So, your body will think it’s still time to be productive and make it harder for you to sleep. Pure Rest can help sync your body with the natural light–dark cycle to support a more natural sleep pattern.*

Pure Rest also protects your health at the cellular level while it helps you sleep. Melatonin can act as a free-radical scavenger. Plus, it helps support your body’s own natural antioxidant enzymes. So, by defending against cell-damaging oxidative stress, Pure Rest offers even more benefits for the restorative processes your body undergoes while asleep.*

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Key Ingredients

Melatonin

See full list of ingredients

Usage

Adults take 1/2 to 2 dissolvable tablets, as needed, one hour before bedtime for relief of occasional sleeplessness.

Insomnia may be a symptom of serious underlying medical illness. Keep out of reach of children. Consult your physician if you are pregnant, nursing, taking a prescription drug, or have a medical condition. Do not drive or operate machinery when taking melatonin.

Ideal For

Adults who need help supporting their normal sleep-and-wake cycle
Travelers
Anyone who needs to reset his or her sleep schedule

Frequently Asked Questions About Pure Rest

Who should use Pure Rest?

Pure Rest is designed for adults interested in improving the quality of their sleep, as well as those who appreciate the link between quality sleep and overall health. Because melatonin production and sleep quality generally decline with age, melatonin supplements also tend to be popular with individuals over the age of 50.

A number of studies confirm melatonin as an effective way to address jet lag. As such, it is a popular choice for individuals who travel extensively.*

When should I take Pure Rest?

Don’t take it too early or it’ll make you fall asleep! Pure Rest will work most effectively if you take it about an hour before you go to bed. The orange-flavored tablet will dissolve in your mouth without water.

References

Circadian Rhythms. National Institutes of General Medical Sciences. [Internet] [accessed 30 May 2018] Available at https://www.nigms.nih.gov/education/pages/Factsheet_CircadianRhythms.aspx

Han KS, Kim L, Shim I. 2012. Stress and sleep disorder. Exp Neurobiol 21(4): 141-150.

Czeisler CA. 2013. Perspective: casting light on sleep deficiency. Nature 497(7450): S13.

Peuhkuri K, Sihvola N, Korpela R. 2012. Dietary factors and fluctuating levels of melatonin. Food Nutr Res 56: 10.3402/fnr.v56i0.17252.

Ramis MR, et al. 2015. Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review. Curr Med Chem 22(22): 2690-711.

Reiter RJ, Tan DX, Osuna C, Gitto E. 2000. Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci 7(6): 444-58.

Vielma JR, et al. 2014. Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: a review. Acta Trop 137: 31-8.

Hosseinzadeh A, et al. 2016. Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin. J Pineal Res 61(4): 411-425.

Posadzki PP, et al. 2018. Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Med 16(1): 18.

Xie Z, et al. 2017. A review of sleep disorders and melatonin. Neurol Res 39(6): 559-565.

Amstrup AK, Sikjaer T, Mosekilde L, Rejnmark L. 2015. The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial. Nutr J 14: 102.

Leger D, Laudon M, Zisapel N. 2004. Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Am J Med 116(2): 91-5.

Buscemi N, et al. 2005. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 20(12): 1151-8.

van Geijlswijk IM, Korzilius HP, Smits MG. 2010. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 33(12): 1605-14.

Herxheimer A, Petrie KJ. 2002. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev (2): CD001520.

Meerlo P, Sgoifo A, Suchecki D. 2008. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Med Rev 12(3): 197-210.

Trivedi MS, et al. 2015. Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status. PLoS One 12(7): e0181978.

Grander M, Hale L, Moore M, Patel N. 2010. Mortality Associated with Short Sleep Duration: The Evidence, The Possible Mechanisms, and The Future. Sleep Med Rev 14(3): 191-203.

Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Institute of Medicine Committee on Sleep Medicine and Research [Internet] [accessed 30 May 2018] Available at https://www.ncbi.nlm.nih.gov/books/NBK19961/

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See the World Through Healthy Eyes with USANA Visionex® and Visionex DS*

USANA Visionex
Visionex DS

Focus on eye health with a vision-supporting supplement that delivers the nutrients your eyes need—vitamin C, zinc, lutein, and zeaxanthin.*

Your eyes are the window to the wonders of the world. So, don’t let exposure to the sun or screens dim your outlook. Focus on protecting your eye health and maintaining your vision with proper nutrition. Set your sights on the important nutrients found in USANA Visionex and Visionex DS.*

Ophthalmologists recommend a diet rich in fruits and vegetables to keep eyes in tip-top shape. And, many recommend adding an advanced eye-health supplement—with specific nutrients—to your daily routine. Visionex supplies nutrients your eyes need to stay sharp.

Visionex is loaded with vitamin C and zinc. It also delivers the phytonutrients lutein, zeaxanthin, and bilberry. Together, these ingredients support many aspects of health:*

Maintaining long-term eye health by fighting free-radical damage*
Acting as blue-light filters to help maintain good eye health and vision*
Aiding the brain through neural support and antioxidant activity*
Maintaining skin health by providing antioxidant defense and supporting collagen and surface lipids*

You can look out for your precious eyes with the nutritional support they require. The CellSentials will help provide a nutritional foundation for your overall health, which includes your eyes. And you can make maintaining healthy eyes a top priority by also including two tablets of Visionex in your daily supplement regimen. Or to get the same amount of lutein and zeaxanthin in only one tablet, try Visionex DS.*

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Eye Anatomy 101

To understand how Visionex can help maintain good eye health, you first need to understand how vision works. The brain and your nervous system also get involved, but it all starts with your eyes.*

The human eye detects radiation (or light) in a specific part of the spectrum—visible light. Then your eyes can form images of objects either directly in front of you, or as far as many miles away. They can even respond to a single particle of light.

This is possible because of the high concentration of sensory receptors found in the eye. In fact, your eyes contain over 70 percent of all sensory receptors in the body.

But your eye is only collecting and focusing light. Your brain translates the messages the eye perceives so you can see the world around you. To understand vision, you need to know how the eye, brain, and optic nerves work together to visually interpret your world.

Processing of visual information begins in the retina and macula in your eye. What you actually see is the light that strikes the retina—a light-sensitive layer of cells at the back of the eye. In the center of the retina is the macula. The lenses in your eyes focus light on the macula.

This focused light initiates cell-signaling pathways. These pathways transmit light information from the eyes, through the optic nerves, to the primary visual cortex of the brain. That processing center is located at the very back of your head. Ultimately, this process creates images that help you perceive the world around you.

The Central Nervous System and Blood Brain Barrier

Your eyes are considered part of the central nervous system (CNS), because many parts of the eye actually begin as brain tissue during early embryonic development. Additionally, it takes many nerves, along with your brain, to perceive the light your eyes take in as physical objects. The fact that the eyes are part of the CNS is important, because all structures of the central nervous system are protected by something known as the blood-brain barrier.

This barrier consists of a highly selective, semi-permeable membrane that separates the circulating blood from the fluids and structures of the CNS. The blood-brain barrier is formed by especially tight connections between the cells that line blood vessels in and around the central nervous system.

The barrier protects these very delicate structures. To do so, it allows only a few select molecules, nutrients, and chemicals to pass. Not all nutrients make it through to the CNS. Thus, to get nutrients into the eye, you must selectively target compounds known to cross the blood-brain barrier.

To do their part in vision, your eyes depend on many nutrients to help you see the world around you. Take a look at some supplied by Visionex:

Vitamin C: This powerful antioxidant and essential nutrient is found in fruits and vegetables. It supports healthy capillaries, gums, teeth, and cartilage. Vitamin C can be found in virtually every cell in the body, and its concentration is significantly higher in the retina than in the blood. Since the human body does not make vitamin C, it must be consumed as part of the diet.*
Zinc: As an essential trace mineral, zinc is necessary for many aspects of health. And it’s found in high concentrations in the eye. It plays a critical role in transporting vitamin A to the retina. Zinc deficiency has been linked to poor night vision. This mineral appears to provide antioxidant protection and promote good visual acuity.*
Lutein & Zeaxanthin: These two carotenoids are selectively transported across the blood-brain barrier and deposited in the macula of the eye. They serve as antioxidants, which help to neutralize free radicals and reduce oxidative stress. Additionally, they help filter out high-energy blue light to support visual acuity.*
Bilberry Extract: The bilberry fruit is rich in antioxidants called anthocyanosides. Bilberry has also been shown to help maintain healthy capillaries, including those in the eye. Healthy capillaries are important because they deliver nutrients to eye tissue. The eyes need plenty of nutrition because vision churns through a lot of energy.*

Visionex harnesses the free-radical-fighting and vision-supporting benefits of these nutrients. And puts them to work for you. By armoring yourself with supportive nutrition, you will continue to support healthy vision and eyes.*

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Visionex Works to Make You the Picture of Ocular Health*

The eye (especially the macula) is prone to photo- and oxidative-damage. This comes from multiple sources:

Natural sunlight
Artificial light from certain types of light bulbs or from computer screens and mobile phones
Exposure to environmental pollutants
Oxidants produced as a result of the high metabolic rate of the eye

Over time, these insults add up and there can be a general decline in visual acuity as you age.

A top concern are the damaging rays from the sun that enter the eye. Just like sunlight (ultraviolet radiation, to be specific) can burn and damage your skin, these same rays can damage structures of the eye.

This is an interesting dilemma for the eyes to balance. On one hand, eyes need to let light in so you can see. But on the other hand, they have to minimize how much light comes in to help protect against damage. To help combat the harmful effects of light, eyes developed an interesting mechanism—concentrating specific protective nutrients.

Some of these nutrients include vitamin C, zinc, lutein, zeaxanthin, and the flavonoid bilberry. Flavonoids, which are a type of plant compound, and vitamin C help promote healthy blood vessels to ensure nutrient delivery. Vitamin C and zinc work together to provide antioxidant protection. Zinc additionally helps to transport vitamin A, an essential nutrient for vision, into the eye. *

The central portion of the macula contains a dense, yellow pigment called macular pigment. This helps protect the sensitive light receptors in the macula from the potentially harmful effects of high-intensity, shorter wavelengths of light (also referred to as blue light). The nutrients that make up this macular pigment are carotenoids, including lutein and zeaxanthin.

A Quick Guide to Carotenoids

Carotenoids make up a very large family of over 750 naturally-occurring plant pigments. They are the compounds in fruits and vegetables that tend to give them their red, orange, and yellow color. With all the different carotenoids found in nature, the eye has developed the ability to specifically and selectively concentrate lutein and zeaxanthin in the eye, specific neurons involved in vision, and certain regions of the brain. Together with these other nutrients, the eye is well equipped to cope with daily stresses.

Because your body cannot make lutein, zeaxanthin, vitamin C, zinc, and bilberry, they must be obtained from the diet or a nutritional supplement. Research has shown that levels of these eye-protecting nutrients correlate to the amount you consume. So, levels of these nutrients increase in a few days and continue to increase as long as they are being consumed. Unfortunately, once consumption of these nutrients stops, levels begin to decline as rapidly as they increased. Therefore, it is important to consistently eat a healthy diet and take a nutritional supplement that supports eye health.*

As you age, macular pigment density tends to decline. Research over the past twenty years has been geared toward understanding how this age-related decrease is related to nutrition. Now scientists have a better understanding of how nutrition helps support vision and maintain long-term eye health.*

The first AREDS research (Age-Related Eye Disease Study) was sponsored by the National Eye Institute. Previous studies linked eye health and nutrition, but AREDS sought to more deeply explore the potential connection.

For study participants, the tie between eye health and a daily recommended intake of nutrients like vitamin C, zinc, lutein, and zeaxanthin was strong. The results of the first AREDS confirmed the link between nutrition and eye health. And additional studies support the findings.*

The formula of Visionex is no accident—it’s based on solid science, including AREDS. Vitamin C, zinc, lutein, and zeaxanthin can help lighten the load of ocular burdens. They reinforce the health of macular pigment to protect your eyes from damaging sunlight. And as antioxidants, they maintain your eyesight by defending against oxidative damage to the delicate tissues of the eye caused by light.*

Along with Visionex, eating a healthy diet and practicing eye-protective habits can help your eyes stay healthy, even as you age. That means avoiding direct exposure to the sun by wearing sunglasses. You should also take regular breaks from computer and smartphone screens.

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Keep Your Vision Sharp Through the Power of Visionex*

Your eyes guide you through your world, so their health can have a noticeable impact on your life. Healthy eyes ensure high visual performance across situations like driving a car or playing sports.

Since time in front of computer screens and cell phones is on the rise, it is necessary to protect your eyes from stress and fatigue. You want your eyes to perform well while you are working. But you also need them to be on top of their game when you get behind the wheel or step onto the field.

Scientific research has shown that nutritional interventions (like dietary supplementation) can help support visual performance.

A 2005 study put this theory to the test with 40 young, healthy subjects (average age of 23.9 years). They were assigned to receive daily supplements of lutein (10 mg) and zeaxanthin (2 mg) for six months. The subjects’ eyes were then tested for the effects of glare as experienced in everyday situations. That included being outdoors on bright days, lengthy sessions of computer time, and nighttime exposure to oncoming headlights.

Following the six months of supplementation, the participants saw positive impacts on macular pigment optical density (MPOD) when compared to average values at the beginning of the study. MPOD levels have been linked with visual acuity. After testing the subjects for their performance on visual tasks, researchers concluded that four to six months of lutein and zeaxanthin supplementation supports visual performance in high-glare situations.

Supplementation with the lutein and zeaxanthin in Visionex can help preserve visual function. Use of these important carotenoids has a number of benefits:*

Sustains tolerance to and recovery from exposure to bright light*
Supports visual acuity in low-light or hazy conditions*
Can help maintain healthy vision by making edges appear clearer*

Reboot your eye health with the nutrients found in Visionex. The lutein and zeaxanthin in USANA’s eye supplement helps support the blue light-filtering power of the macula and provides antioxidants to fight off oxidative damage.*

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Think Visionex For Extra Brain Benefits*

The benefits of Visionex extend beyond your eyes. That’s because lutein and zeaxanthin can cross the blood-brain barrier. So, after these carotenoids are deposited in the macula, they also have work to do supporting healthy brain function.*

What accounts for the cognitive effects? Your brain puts lutein and zeaxanthin to use helping to optimize the speed and efficiency of sending messages in your brain.*

The first way this may work is supporting the speed at which signals are sent down a neuron. This could be the result of the antioxidant properties of lutein and zeaxanthin shuttling electrons and other signals along the neuron.*

The second possibility is that lutein and zeaxanthin support specific cell-signaling pathways. These pathways turn on the gene responsible for holding neurons tightly against each other at connections called tight junctions. Think of these as the glue that keeps cells in close contact. More glue means a strong, tight connection.*

Why would this connection be important? Neurons need to send messages down the length of their cells, as well as between cells. The tighter the connections, the more efficiently the signal is sent and received. Supporting signaling efficiency equals optimal cellular communication.*

Increasing the amount of this cellular glue may help the brain form new connections and cell-signaling pathways. Both are very important for learning and memory.*

Because it supports the brain’s ability to send and receive messages, Visionex is an excellent companion product to CopaPrime+, which uses USANA InCelligence Technology™ to support peak cognitive function.*

Research has shown high levels of circulating carotenoids, specifically lutein and zeaxanthin, support many brain functions. They include the following:*

Learning
Memory
Verbal fluency
Reaction time
Balance
Neural efficiency (processing speed)

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Eye-Spy Youthful Skin with Help from Visionex

Lutein and zeaxanthin also offer benefits for supporting your skin’s healthy appearance. They do this by increasing surface lipids (fats) and enhancing natural antioxidant activity. By concentrating in the skin, they help provide protection from light to reduce the visible effects of the sun.

By promoting lipid production, lutein and zeaxanthin foster healthy cell growth. Skin cells are some of the fastest growing cells in the body. So, they need the support of nutrients like lutein and zeaxanthin to guard your body with a beautiful and protective outer layer.*

The vitamin C in Visionex acts as an antioxidant and also supports the synthesis of collagen, which is an important structural protein in the skin.*

The antioxidants in Visionex help protect skin from a dry or prematurely wrinkled appearance that could be caused by environmental exposure. When paired with a broad-spectrum sunscreen applied to the skin to defend against the effects of the sun, Visionex can help maintain your healthy glow from the inside.*

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