USANA Research

Science has been at the heart of USANA since the very beginning, over 25 years ago. The company’s research and development (R&D) team is focused on developing high-quality, science-based products that help support long-term health.

USANA’s R&D team includes experts on human nutrition, cellular biology, biochemistry, genetics, the microbiome, as well as medical doctors. In addition to product research, USANA maintains a staff of scientists dedicated to the manufacturing and quality control of its products.

The company also has relationships and collaborates on research with a number of universities and research institutes. This includes the University of Washington; the University of Texas Medical Branch, Galveston, Texas; the University of Utah; The Foods for Health Institute at The University of California, Davis; and The University of North Carolina at Pembroke.

Read below to learn about USANA’s newest research, patents, and past research that went into developing existing products.

Catch Up on USANA’s Newest Research

Advanced Doses of Vitamin D are Required to Achieve Optimal Vitamin D Status, Particularly During the Winter

A Novel Assay for Determining Plasma Antioxidant Capacity

Bioavailability of Epicatechin after Consumption of Grape Seed Extract in Humans

Bioavailability of Silicon from Three Sources

Bioavailability of USANA Essentials vs Four Select Competitor Products

Calcium-Magnesium-Vitamin D Supplementation Improves Bone Mineralization in Preadolescent Girls

Comparative Absorption of Water Soluble Vitamins from Five Supplements

Comparative Bioavailability of Coenzyme Q10 in Four Formulations

Effects of Antioxidant Supplementation on Oxidative Stress in Trained Cyclists

Effects of Broad-Spectrum Antioxidant Supplementation on the Antioxidant Status of Human Plasma

Genetic and Epigenetic Signature Identifies Individuals with Elevated Response to Vitamin B12 Supplementation

Genetic Risk of Methylene Tetrahydrofolate Reductase Single Nucleotide Polymorphism on Blood Homocysteine is Dependent on Sex, Race, and Supplement Use

Glycemic Index (GI) Scores for USANA’s Chocolate, Vanilla, and Strawberry Nutrimeals

Glycemic Index (GI) Score for USANA’s Fibergy Bar and Chocolate Nutrimeal

Glycemic Index (GI) Score for USANA’s Peanut Butter Crunch Nutrition Bar

Grape Seed Extract Plus Vitamin C Improves Indices of Vascular Health

Hepasil DTX™ Increases Antioxidant and Detoxification Capacity by Boosting Glutathione and Vitamin C (1)

Hepasil DTX™ Increases Antioxidant and Detoxification Capacity by Boosting Glutathione and Vitamin C (2)

Method of Assessment of Antioxidant Status In Vivo

Pharmacokinetics of Poly C versus Ascorbic Acid

Short-term CellSentials Supplementation Significantly Improves the Quality of Life Metrics of Essentials Users

Ubiquinone versus Ubiquinol Clinical Research Bulletin

USANA CellSentials® Supplementation Significantly Increases Circulating Serum Nutrient Levels

Vitamin D Supplementation is Required During the Winter to Obtain Optimal Vitamin D Status

Brown M, Cuomo J, Tian J, USANA Health Sciences, Inc. 2017. U.S Patent No 10,632,101 Salt Lake City, UT: U.S. Patent and Trademark Office.

McDonald JH, McDonald SC, Lundmark LD, Kabara JJ, Garruto JA, USANA Health Sciences, Inc. 2007. U.S. Patent No 7,214,391. Salt Lake City, UT: U.S. Patent and Trademark Office.

Cuomo J, Rabovsky AB, USANA Health Sciences, Inc. 2002. U.S. Patent No 6,361,803. Salt Lake City, UT: U.S. Patent and Trademark Office.

Cuomo J, Rabovsky AB, USANA Health Sciences, Inc. 2002. U.S. Patent No 6,358,542. Salt Lake City, UT: U.S. Patent and Trademark Office.

Bosse JD, Dixon BM. Dietary protein in weight management: a review proposing protein spread and change theories. Nutr Metab (Lond). 2012;9(1):81.

Bosse JD, Dixon BM. Dietary protein to maximize resistance training: a review and examination of protein spread and change theories. J Int Soc Sports Nutr. 2012;9(1):42.

Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. 2011. J Nat Prod 74(4):664-9.

Eich N, Schneider E, Cuomo J, Rabovsky A, Vita JA, Palmisano J, Holbrook M. Bioavailability of epicatechin after consumption of grape seed extract in humans. FASEB. 2007;21(6).

Enomoto, AC, Schneider, E, McKinnon, T, Goldfine, H, Levy, MA. Validation of a simplified procedure for convenient and rapid quantification of reduced and oxidized glutathione in human plasma by liquid chromatography tandem mass spectrometry analysis. Biomedical Chromatography. 2020; 34:e4854.

Gamache P, Rabovsky A, Cuomo J. Lipoic acid analysis in food supplements by HPLC with Coulometric Array Detector. 1999. Presentation, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Pittsburgh, Pennsylvania, USA.

Ivanov V, Rabovsky A. Extracellular Matrix Regulates Proliferation Rate of Vascular Smooth Muscle Cells: Role of Hyaluronic acid. 1996. Abstract Presentation, Becton Dickinson Symposium on Extracellular Matrix, ECM Interactions, London, UK.

Jin H, Cheng H, Chen W, et al. An evidence-based approach to globally assess the covariate-dependent effect of the MTHFR single nucleotide polymorphism rs1801133 on blood homocysteine: a systematic review and meta-analysis. Am J Clin Nutr. 2018;107(5):817-825.

Jin H, Maddela Rolando L, Sinnott Robert A. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences. 2020;8(5)127-138.

Jin H, Nicodemus-Johnson J. Gender and Age Stratified Analyses of Nutrient and Dietary Pattern Associations with Circulating Lipid Levels Identify Novel Gender and Age-Specific Correlations. Nutrients. 2018;10(11).

Levy MA, Mckinnon T, Barker T, et al. Predictors of vitamin D status in subjects that consume a vitamin D supplement. Eur J Clin Nutr. 2015;69(1):84-9.

Levy M A, McKinnon T, Goldfine H, Enomoto A, Schneider E, Cuomo J. Consumption of a multivitamin/multimineral supplement for 4 weeks improves nutritional status and markers of cardiovascular health. Journal of Functional Foods. 2019;62.

Levy M, Wu JR, Shi JP, et al. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults. Chin J Integr Med. 2021;27(9):666-673.

Mazumder P, Chuang HY, Wentz MW, Wiedbrauk DL. Latex agglutination test for detection of antibodies to Toxoplasma gondii. J Clin Microbiol. 1988;26(11):2444-6.

McDonald J, Preobrazhensky S, Malugin A, Rabovsky A, Wood T, Wentz M. Effect of Vitamin E Supplementation on susceptibility to oxidation of isolated low density lipoprotein and apolipoprotein B-100 in unfractionated blood. 1997. Abstract Presentation, XI International Symposium on Atherosclerosis, Paris, France.

Nicodemus-johnson J, Sinnott RA. Fruit and Juice Epigenetic Signatures Are Associated with Independent Immunoregulatory Pathways. Nutrients. 2017;9(7).

Preobrazhensky S, Malugin A, Wentz M. Flow cytometric assay for evaluation of the effects of cell density on cytotoxicity and induction of apoptosis. Cytometry. 2001;43(3):199-203.

Preobrazhensky S, Rabovsky A, Goldmacher V, Wentz M. Comparative study of cytotoxic action of low density lipoprotein and cumene hydroperoxide on various lymphoid cell lines. 1997. XI International Symposium on Atherosclerosis, Paris, France.

Preobrazhensky S, Trakht I, Chestkov V, Wentz M. Monoclonal antibody-based immunoassay for evaluation of lipoprotein oxidation. Analytical Biochemistry. 1995;227(1):225-34.

Rabovsky A, Cuomo J. Olive oil: Direct measure of antioxidant activity. Free Rad Bio Med 1999;27(Supp 1):S42.

Rabovsky A, Cuomo J, Eich N. Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects. Clin Chim Acta. 2006;371(1-2):55-60.

Rabovsky A, Cuomo J, Wentz M. Inhibition of fat absorption with grape seed antioxidants. Free Rad Bio Med 1998;25(Supp 1):96.

Rabovsky A, Preobrazhensky S, Wentz M. In vitro antioxidant activity of flavonoids measured using different procedures. 1996. Abstract Presentation, 3rd Annual Meeting of the Oxygen Society, Miami Beach, Florida, USA.

Rabovsky A, Preobrazhensky S, Wentz M. Protection of cultured human cells from oxidative damage by alpha-tocopherol, ascorbic acid and flavonoids. 1996. Abstract Presentation, VIII Biennial Meeting International Society for Free Radical Research, Barcelona, Spain.

Rabovsky A, Preobrazhensky S, Wentz M. Synergistic action of Ascorbic Acid and Bioflavonoids in protecting Apolipoprotein B from oxidation. 1996. Abstract Presentation, VIII Biennial Meeting International Society for Free Radical Research, Barcelona, Spain.

Tian JJ, Levy M, Zhang X, Sinnott R, Maddela R. Counteracting health risks by Modulating Homeostatic Signaling.2022. Pharmacol Res. 2022;182:106281.

Ball SD, Keller KR, Moyer-mileur LJ, Ding YW, Donaldson D, Jackson WD. Prolongation of satiety after low versus moderately high glycemic index meals in obese adolescents. Pediatrics. 2003;111(3):488-94.

Barker T, Leonard SW, Trawick RH, et al. Modulation of inflammation by vitamin E and C supplementation prior to anterior cruciate ligament surgery. Free Radic Biol Med. 2009;46(5):599-606.

Barker T, Leonard SW, Trawick RH, Walker JA, Traber MG. Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery. Redox Rep. 2009;14(5):221-6.

Barker T, Leonard SW, Hansen J, et al. Vitamin E and C supplementation does not ameliorate muscle dysfunction after anterior cruciate ligament surgery. Free Radic Biol Med. 2009;47(11):1611-8.

Barker T, Traber MG. Does vitamin E and C supplementation improve the recovery from anterior cruciate ligament surgery? Journal of Evidenced-Based Complementary & Alternative Medicine. 2011;16:114-128.

Barker T, Martins TB, Hill HR, et al. Vitamins E and C modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery. Am J Phys Med Rehabil. 2011;90(8):638-47.

Barker T, Martins TB, Hill HR, et al. Low vitamin D impairs strength recovery after anterior cruciate ligament surgery. Journal of Evidenced-Based Complementary & Alternative Medicine. 2011;16(3):201-209.

Barker T, Martins TB, Hill HR, et al. Different doses of supplemental vitamin D maintain interleukin-5 without altering skeletal muscle strength: a randomized, double-blind, placebo-controlled study in vitamin D sufficient adults. Nutr Metab (Lond). 2012;9(1):16.

Barker T, Martins TB, Kjeldsberg CR, Trawick RH, Hill HR. Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio. Cytokine. 2012;60(1):23-6.

Barker T, Martins TB, Hill HR, et al. Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults. Eur J Appl Physiol. 2013;113(6):1523-34.

Barker T, Henriksen VT, Martins TB, et al. Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients. 2013;5(4):1253-75.

Barker T, Schneider ED, Dixon BM, Henriksen VT, Weaver LK. Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise. Nutr Metab (Lond). 2013;10(1):69.

Barker T, Martins TB, Hill HR, et al. Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans. Cytokine. 2014;65(2):134-7.

Barker T, Henriksen VT, Rogers VE, et al. Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis. Redox Biol. 2014;2:466-74.

Barker T, Rogers VE, Henriksen VT, et al. Serum cytokines are increased and circulating micronutrients are not altered in subjects with early compared to advanced knee osteoarthritis. Cytokine. 2014;68(2):133-6.

Barker T, Rogers VE, Henriksen VT, et al. Muscular-based and patient-reported outcomes differentially associate with circulating superoxide dismutases and cytokines in knee osteoarthritis. Cytokine. 2019;115:45-49.

Barker T, Rogers VE, Levy M, et al. Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: a randomized, double blind, placebo-controlled study. Cytokine. 2015;71(2):132-8.

Bemer B, Krueger SK, Orner GA. Sulindac pharmacokinetics. The role of flavin-containing monooxygenases. 2008. Howard Hughes Medical Institute, Summer Internship Presentation, Oregon State University, September 26.

Best T, Clarke C, Nuzum N, Teo WP. Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study. Nutr Neurosci. 2019;:1-12.

Best T, Miller J, Teo WP. Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults – a randomised, double-blind, placebo-controlled study. Nutritional Neuroscience. 2024;1-13.

Bloomer, R. , Pence, J. , Davis, A. and Stockton, M. Weight Loss and Improved Metabolic Health Measures Using a One-Week Active Nutrition Jumpstart Program in Overweight and Obese Men and Women. Health. 2023.;15, 640-653.

Dixon BM, Barker T, Mckinnon T, et al. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults. BMC Res Notes. 2012;5:575.

Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007;137(11):2405-11.

Frei B, Birlouez-aragon I, Lykkesfeldt J. Authors’ perspective: What is the optimum intake of vitamin C in humans?. Crit Rev Food Sci Nutr. 2012;52(9):815-29.

Greene DA, Naughton GA. Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial. 2010. Osteoporosis International, in review.

Guo X, Xu Y, He H, et al. Effects of a Meal Replacement on Body Composition and Metabolic Parameters among Subjects with Overweight or Obesity. J Obes. 2018;2018:2837367.

Guo X, Xu Y, He H, et al. Visceral fat reduction is positively associated with blood pressure reduction in overweight or obese males but not females: an observational study. Nutr Metab (Lond). 2019;16:44.

Henriksen VT, Rogers VE, Rasmussen GL, et al. Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty?. Med Hypotheses. 2014;82(2):134-7.

Huang Y, Chen Y, Shaw AM, Goldfine H, Tian J, Cai J. Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin. Oxid Med Cell Longev. 2018;2018:5073420.

Johnson S, Hagen TM. Changes in Acute Human Plasma Glutathione Levels Following Lipoic Acid Supplementation. Howard Hughes Medical Institute Summer Internship presentation, Oregon State University, September 24, 2009, and Center for Health Aging Research Life Scholars presentation, Oregon State University, October 14, 2009.

Jubert C, Mata J, Bench G, et al. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prev Res (Phila). 2009;2(12):1015-22.

Junrong W, Haojie c, Jianpin S, et al. Development and validation of a diagnostic risk score for assessing a TCM condition, Protective Qi Deficiency, in adults. Eu J Int Med. 2020;35(101097).

Kang JW, Tang X, Walton CJ, et al. Multi-Omic Analyses Reveal Bifidogenic Effect and Metabolomic Shifts in Healthy Human Cohort Supplemented With a Prebiotic Dietary Fiber BlendFront Nutr. 2022;9:908534.

Kesinger NG, Langsdorf BL, Yokochi AF, Miranda CL, Stevens JF. Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal. Chem Res Toxicol. 2010;23(4):836-44.

Lee MB, Kiflezghi MG, Tsuchiya M, et al. Pterocarpus marsupium extract extends replicative lifespan in budding yeast. Geroscience. 2021;43(5):2595-2609.

Levy MA, Tian J, Gandelman M, et al. A Multivitamin Mixture Protects against Oxidative Stress-Mediated Telomere Shortening. J Diet Suppl. 2024;21(1):53-70.

Leonard SW, Barker T, Mustacich DJ, Traber MG. Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS. FASEB. 2010;24(Supp 1).

Lotito SB, Zhang WJ, Yang CS, Crozier A, Frei B. Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med. 2011;51(2):454-63.

Michels AJ, Dickinson BC, Chang CJ, Frei B. Generation of H2O2 by ascorbate auto-oxidation: possible implications for cancer therapy. 2010. Society for Free Radical Biology and Medicine Annual Meeting, Orlando, FL.

Peluso MR, Miranda CL, Hobbs DJ, Proteau RR, Stevens JF. Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). Planta Med. 2010;76(14):1536-43.

Song Y, Chung CS, Bruno RS, et al. Dietary zinc restriction and repletion affects DNA integrity in healthy men. Am J Clin Nutr. 2009;90(2):321-8.

Song Y, Chung CS, Bruno RS, Traber MG, Brown KH, King JC, Ho E. Zinc status affects DNA damage and oxidative stress in healthy adult men. FASEB. 2009;23(Supp 1).

Song Y, Ho E. Effects of zinc deficiency on DNA damage, oxidative stress and oxidant defense in peripheral blood. FASEB. 2008;22(Supp 1).

Traber MG, Barker T. Vitamins E and C in ACL (Anterior Cruciate Ligament) Injury. 2009. 3rd International Symposium; Nutrition, Oxygen Biology and Medicine. Paris, France.

Wolinsky LE, Cuomo J, Quesada K, Bato T, Camargo PM. A comparative pilot study of the effects of a dentifrice containing green tea bioflavonoids, sanguinarine or triclosan on oral bacterial biofilm formation. J Clin Dent. 2000;11(2):53-9.

Wu JR, Cheng HJ, Shi JP, et al. β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial. Chin J Integr Med. 2021;10.

Wyatt HR, Ogden LG, Cassic KS, Hoagland EA, McKinnon T, Eich N, Chernyshev V, Wood T, Cuomo J, Hill JO. Successful internet-based lifestyle change program on body weight and markers of metabolic health. Obesity and Weight Management. 2009;5(4):167-73.

Yilmazer-musa M, Griffith AM, Michels AJ, Schneider E, Frei B. Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. J Agric Food Chem. 2012;60(36):8924-9.

Yilmazer-Musa M, Tucker AM, Frei B. Inhibition of a-amylase and a-glucosidase activity by bioflavonoids: implications for carbohydrate metabolism and type-2 diabetes. Free Radical Biology and Medicine. 2010;49(S37).

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