USANA研究
从25年前的最早期开始，科学一直是USANA的核心。本公司的研发（R&D）团队一直以来都致力于开发以科学为基础的高质量产品来帮助维持长期健康。
USANA的研发团队成员包括人类营养、细胞生物学、生物化学、遗传学、微生物组等专家以及医生。除了产品研究外，USANA还拥有一群致力于产品制造与质检的科学家工作人员。
此外，公司也与多所大学及研究机构建立合作研究关系，其中包括华盛顿大学、德州加尔维斯顿的德州大学医学院、犹他大学、加州大学戴维斯分校健康食品研究所，以及北卡罗来纳大学彭布罗克分校。
欲了解USANA的最新研究、专利以及用于开发现有产品的先前的研究报告，请阅读以下内容。（研究报告仅提供英文版。）
一览USANA的最新研究成果
USANA公司内部研究
A Novel Assay for Determining Plasma Antioxidant Capacity
Bioavailability of Epicatechin after Consumption of Grape Seed Extract in Humans
Bioavailability of Silicon from Three Sources
Bioavailability of USANA Essentials vs Four Select Competitor Products
Calcium-Magnesium-Vitamin D Supplementation Improves Bone Mineralization in Preadolescent Girls
Comparative Absorption of Water Soluble Vitamins from Five Supplements
Comparative Bioavailability of Coenzyme Q10 in Four Formulations
Effects of Antioxidant Supplementation on Oxidative Stress in Trained Cyclists
Effects of Broad-Spectrum Antioxidant Supplementation on the Antioxidant Status of Human Plasma
Glycemic Index (GI) Scores for USANA’s Chocolate, Vanilla, and Strawberry Nutrimeals
Glycemic Index (GI) Score for USANA’s Fibergy Bar and Chocolate Nutrimeal
Glycemic Index (GI) Score for USANA’s Peanut Butter Crunch Nutrition Bar
Grape Seed Extract Plus Vitamin C Improves Indices of Vascular Health
Method of Assessment of Antioxidant Status In Vivo
Pharmacokinetics of Poly C versus Ascorbic Acid
Ubiquinone versus Ubiquinol Clinical Research Bulletin
USANA CellSentials® Supplementation Significantly Increases Circulating Serum Nutrient Levels
Vitamin D Supplementation is Required During the Winter to Obtain Optimal Vitamin D Status
USANA专利
Brown M, Cuomo J, Tian J, USANA Health Sciences, Inc. 2017. U.S Patent No 10,632,101 Salt Lake City, UT: U.S. Patent and Trademark Office.
McDonald JH, McDonald SC, Lundmark LD, Kabara JJ, Garruto JA, USANA Health Sciences, Inc. 2007. U.S. Patent No 7,214,391. Salt Lake City, UT: U.S. Patent and Trademark Office.
Cuomo J, Rabovsky AB, USANA Health Sciences, Inc. 2002. U.S. Patent No 6,361,803. Salt Lake City, UT: U.S. Patent and Trademark Office.
Cuomo J, Rabovsky AB, USANA Health Sciences, Inc. 2002. U.S. Patent No 6,358,542. Salt Lake City, UT: U.S. Patent and Trademark Office.
经过内部同行评审的USANA内部研究报告
Bosse JD, Dixon BM. Dietary protein in weight management: a review proposing protein spread and change theories. Nutr Metab (Lond). 2012;9(1):81.
Bosse JD, Dixon BM. Dietary protein to maximize resistance training: a review and examination of protein spread and change theories. J Int Soc Sports Nutr. 2012;9(1):42.
Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. 2011. J Nat Prod 74(4):664-9.
Eich N, Schneider E, Cuomo J, Rabovsky A, Vita JA, Palmisano J, Holbrook M. Bioavailability of epicatechin after consumption of grape seed extract in humans. 2007. FASEB 21:lb289.
, , , , . Validation of a simplified procedure for convenient and rapid quantification of reduced and oxidized glutathione in human plasma by liquid chromatography tandem mass spectrometry analysis. Biomedical Chromatography. 2020; 34:e4854.
Gamache P, Rabovsky A, Cuomo J. Lipoic acid analysis in food supplements by HPLC with Coulometric Array Detector. 1999. Presentation, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Pittsburgh, Pennsylvania, USA.
Ivanov V, Rabovsky A. Extracellular Matrix Regulates Proliferation Rate of Vascular Smooth Muscle Cells: Role of Hyaluronic acid. 1996. Abstract Presentation, Becton Dickinson Symposium on Extracellular Matrix, ECM Interactions, London, UK.
Jin H, Cheng H, Chen W, et al. An evidence-based approach to globally assess the covariate-dependent effect of the MTHFR single nucleotide polymorphism rs1801133 on blood homocysteine: a systematic review and meta-analysis. Am J Clin Nutr. 2018;107(5):817-825.
Jin H, Maddela Rolando L, Sinnott Robert A. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences. 2020;8(5)127-138.
Jin H, Nicodemus-Johnson J. Gender and Age Stratified Analyses of Nutrient and Dietary Pattern Associations with Circulating Lipid Levels Identify Novel Gender and Age-Specific Correlations. 2018. Nutrients 10(11), 1760.
Levy M A, McKinnon T, Barker T, Dern A, Helland T, Robertson J, Cuomo J, Wood T, Dixon B M. Predictors of vitamin D status in subjects that consume a vitamin D supplement. 2014. Eur J Clin Nutr.
Levy M A, McKinnon T, Goldfine H, Enomoto A, Schneider E, Cuomo J. Consumption of a multivitamin/multimineral supplement for 4 weeks improves nutritional status and markers of cardiovascular health. 2019. Journal of Functional Foods.
Levy M, Wu JR, Shi JP, et al. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults. Chin J Integr Med. 2021;27(9):666-673.
Mazumder P, Chuang HY, Wentz MW, Wiedbrauk DL. Latex agglutination test for detection of antibodies to Toxoplasma gondii. 1988. J Clin Microbiol 26(11):2444-6.
McDonald J, Preobrazhensky S, Malugin A, Rabovsky A, Wood T, Wentz M. Effect of Vitamin E Supplementation on susceptibility to oxidation of isolated low density lipoprotein and apolipoprotein B-100 in unfractionated blood. 1997. Abstract Presentation, XI International Symposium on Atherosclerosis, Paris, France.
Preobrazhensky S, Malugin A, Wentz M. Flow cytometric assay for evaluation of the effects of cell density on cytotoxicity and induction of apoptosis. 2001. Cytometry 43(3):199-203.
Preobrazhensky S, Rabovsky A, Goldmacher V, Wentz M. Comparative study of cytotoxic action of low density lipoprotein and cumene hydroperoxide on various lymphoid cell lines. 1997. XI International Symposium on Atherosclerosis, Paris, France.
Preobrazhensky S, Trakht I, Chestkov V, Wentz M. Monoclonal antibody-based immunoassay for evaluation of lipoprotein oxidation. 1995. Analytical Biochemistry 227(1):225-34.
Rabovsky A, Cuomo J. Olive oil: Direct measure of antioxidant activity. 1999. Free Rad Bio Med 27(Supp 1):S42.
Rabovsky A, Cuomo J, Eich N. Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects. 2006. Clinica Chimica Acta 371(1-2):55-60.
Rabovsky A, Cuomo J, Wentz M. Inhibition of fat absorption with grape seed antioxidants. 1998. Free Rad Bio Med 25(Supp 1):96.
Rabovsky A, Preobrazhensky S, Wentz M. In vitro antioxidant activity of flavonoids measured using different procedures. 1996. Abstract Presentation, 3rd Annual Meeting of the Oxygen Society, Miami Beach, Florida, USA.
Rabovsky A, Preobrazhensky S, Wentz M. Protection of cultured human cells from oxidative damage by alpha-tocopherol, ascorbic acid and flavonoids. 1996. Abstract Presentation, VIII Biennial Meeting International Society for Free Radical Research, Barcelona, Spain.
Rabovsky A, Preobrazhensky S, Wentz M. Synergistic action of Ascorbic Acid and Bioflavonoids in protecting Apolipoprotein B from oxidation. 1996. Abstract Presentation, VIII Biennial Meeting International Society for Free Radical Research, Barcelona, Spain.
Tian JJ, Levy M, Zhang X, Sinnott R, Maddela R. Counteracting health risks by Modulating Homeostatic Signaling.2022. Pharmacol Res. 2022;182:106281.
与USANA合作进行的第三方研究
Ball SD, Keller KR, Moyer-Mileur LJ, Ding YW, Donaldson D, Jackson WD. Prolongation of satiety after low versus moderately high glycemic index meals in obese adolescents. 2003. Pediatrics 111:488-94.
Barker T, Leonard, SW, Trawick RH, Kjeldsberg CR, Martins TB, Hill HR, & Traber MG (2009). Modulation of Inflammation by Vitamin E and C Supplementation Prior to Anterior Cruciate Ligament Surgery. Free Radical Biology & Medicine. 46; 599-606
Barker T, Leonard SW, Trawick RH, Walker JA, & Traber MG (2009). Antioxidant supplementation lowers circulating IGF-1 but not F2-isoprostanes immediately following ACL surgery. Redox Report. 14; 221-226
Barker T, Leonard SW, Hansen J, Trawick RH, Ingram R, Burdett G, Lebold K, Walker JA, & Traber MG (2009). Vitamin E and C supplementation does not ameliorate muscle dysfunction following anterior cruciate ligament surgery. Free Radical Biology & Medicine. 47; 1611-1618
Barker T & Traber MG (2011). Does vitamin E and C supplementation improve the recovery from anterior cruciate ligament surgery? Journal of Evidenced-Based Complementary & Alternative Medicine. 16; 114-128
Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Leonard SW, Walker JA, & Traber MG (2011). Vitamins E and C supplementation modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery. American Journal of Physical Medicine and Rehabilitation. 90(8); 638-647
Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Weaver LK & Traber MG (2011). Low vitamin D impairs strength recovery after anterior cruciate ligament surgery. Journal of Evidenced-Based Complementary & Alternative Medicine. 16(3); 201-209
Barker T, Martins TB, Kjeldsberg CR, Hill HR, Dixon BM, Schneider ED, Dern A, & Weaver LK (2012). Different doses of supplemental vitamin D mediate disparate interleukin-5 responses without altering skeletal muscle strength in humans: a randomized, double-blind, placebo-controlled study. Nutrition & Metabolism. 9(1). 16
Barker T, Martin TB, Kjeldsberg CR, Trawick RH, & Hill HR (2012). Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio. Cytokine, 60; 23-26
Barker T, Martins TB, Hill HR, Kjeldsberg CR, Dixon BM, Schneider ED, Henriksen VT, & Weaver LK (2013). Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults. European Journal of Applied Physiology, 113; 1523-34
Barker T, Henriksen VT, Martins TB, Hill HR, Kjeldsberg CR, Schneider ED, Dixon BM, & Weaver LK (2013). Serum 25-hydroxyvitamin D predicts muscular weakness after intense exercise. Nutrients, 5; 1253-75
Barker T, Schneider ED, Dixon BM, Henriksen VT, & Weaver LK (2013). Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise: a randomized, double-blind, placebo-controlled study in humans. Nutrition & Metabolism, 10; 1-10
Barker T, Martins TB, Hill HR, Kjeldsberg CR, Dixon BM, Schneider ED, Henriksen VT, & Weaver LK (2014). Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans. Cytokine, 65: 134-137
Barker T, Henriksen VT, Rogers VE, Aguirre D, Trawick RH, Rasmussen GL, & Momberger (2014). Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis. Redox Biology, 2: 466-474
Barker T, Rogers VE, Henriksen VT, Aguirre D, Trawick RH, Rasmussen GL, & Momberger NG (2014). Serum cytokines are increased and circulating micronutrients are not altered in subjects with early compared to advanced knee osteoarthritis. Cytokine, 68: 133-136
Barker T, Rogers VE, Henriksen VT, Dixon B, Momberger N, Rasmussen G, & Trawick R. Muscular-based and patient-reported outcomes differentially associate with circulating superoxide dismutases and cytokines in knee osteoarthritis. 2019. Cytokine, 115, 45-49.
Barker T, Rogers VE, Levy M, Templeton J, Goldfine H, Schneider ED, Dixon BM, Henriksen VT, & Weaver LK (2015). Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study. Cytokine, 71: 132-138.
Bemer B, Krueger SK, Orner GA. Sulindac pharmacokinetics. The role of flavin-containing monooxygenases. 2008. Howard Hughes Medical Institute, Summer Internship Presentation, Oregon State University, September 26.
Best T, Clarke C, Nuzum N, Teo WP. Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study. Nutr Neurosci. 2019;:1-12.
Bloomer, R. , Pence, J. , Davis, A. and Stockton, M. Weight Loss and Improved Metabolic Health Measures Using a One-Week Active Nutrition Jumpstart Program in Overweight and Obese Men and Women. Health. 2023.;15, 640-653.
Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, Borregaard N, Gombart A. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in health adults. BMC Research Notes. 2012;5:575.
Edwards RL, Lyon T, Litwin Se, Rabovsky A, Symons JD, Jalili T. . 2007. J Nutr 137:2405-11.
Frei, B., Birlouez-Aragon, I., and Lykkesfeldt, J. (2012) Authors’ perspective: What is the optimum intake of vitamin C in humans? Crit. Rev. Food Sci. Nutr. 52(9):815-29.
Greene DA, Naughton GA. Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial. 2010. Osteoporosis International, in review.
Henriksen VT, Rogers VE, Rasmussen GL, Trawick RH, Momberger NG, Aguirre D, & Barker T (2014). Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty? Medical Hypotheses, 84: 134-137
Huang Y, Chen Y, Shaw AM, Goldfine H, Tian J, Cai J. Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin. Oxid Med Cell Longev. 2018;2018:5073420.
Johnson S, Hagen TM. Changes in Acute Human Plasma Glutathione Levels Following Lipoic Acid Supplementation. 2009. Howard Hughes Medical Institute Summer Internship presentation, Oregon State University, September 24, 2009, and Center for Health Aging Research Life Scholars presentation, Oregon State University, October 14, 2009.
Jubert C, Mata J, Bench G, Dashwood R, Pereira C, Tracewell W, Turteltaub K, Williams D, Baily G. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B1 pharmacokinetics in human volunteers. 2009. Cancer Prevention Research 2(12):1015-22.
Junrong W, Haojie c, Jianpin S, et al. Development and validation of a diagnostic risk score for assessing a TCM condition, Protective Qi Deficiency, in adults. Eu J Int Med. 2020;35(101097).
Kang JW, Tang X, Walton CJ, et al. Multi-Omic Analyses Reveal Bifidogenic Effect and Metabolomic Shifts in Healthy Human Cohort Supplemented With a Prebiotic Dietary Fiber Blend. Front Nutr. 2022;9:908534.
Kesinger NG, Langsdorf BL, Yokochi AF, Miranda CL, and Stevens JF. Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal. 2010. Chem Res Toxicol 23:836-44.
Lee MB, Kiflezghi MG, Tsuchiya M, et al. Pterocarpus marsupium extract extends replicative lifespan in budding yeast. Geroscience. 2021;43(5):2595-2609.
Levy MA, Tian J, Gandelman M, et al. A Multivitamin Mixture Protects against Oxidative Stress-Mediated Telomere Shortening. J Diet Suppl. 2024;21(1):53-70.
Leonard SW, Barker T, Mustacich DJ, Traber MG. Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS. 2009. Diet and Optimum Health Conference, Portland, OR.
Leonard SW, Barker T, Mustacich DJ, Traber MG. Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS. 2010. Experimental Biology, Anaheim, CA.
Leonard SW, Barker T, Taylor AW, Traber MG. APCI LC-MS quantitation of vitamin K in the plasma of anterior cruciate ligament surgery patients. 20XX. Analytical Biochemistry, in review.
Lotito SB, Zhang WJ, Yang CS, Crozier A, and Frei B. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med 51:454-463.
Michels AJ, Dickinson BC, Chang CJ, Frei B. Generation of H2O2 by ascorbate auto-oxidation: possible implications for cancer therapy. 2010. Society for Free Radical Biology and Medicine Annual Meeting, Orlando, FL.
Moyer-Mileur LJ, Xie B, Ball SD, Pratt T. Bone mass and density response to a 12-month trial of calcium and vitamin D supplement in preadolescent girls. 2003. J Musculoskel Neuron Interact 3(1):63-70.
Peluso MR, Miranda CL, Hobbs DJ, Proteau RR, Stevens JF. Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silicobinding to myeloid differentiation protein-2 (MD-2). 2010. Planta Med 76:1536-43.
Song Y, Chung CS, Bruno RS, Traber MG, Brown KH, King JC, Ho E. Dietary zinc restriction and repletion affects DNA integrity in healthy men. 2009. Am J Clin Nutr 90:321-8.
Song Y, Chung CS, Bruno RS, Traber MG, Brown KH, King JC, Ho E. Zinc status affects DNA damage and oxidative stress in healthy adult men. 2009. FASEB J 23:216.1. (Yang Song won the Young Investigator award with the American Society of Nutrition for this work.)
Song Y, Ho E. Effects of zinc deficiency on DNA damage, oxidative stress and oxidant defense in peripheral blood. 2008. FASEB J 22:A697.
Traber MG, Barker T. Vitamins E and C in ACL (Anterior Cruciate Ligament) Injury. 2009. 3rd International Symposium; Nutrition, Oxygen Biology and Medicine. Paris, France.
Wolinsky LE, Cuomo J, Quesada K, Bato T, Camargo PM. A comparative pilot study of the effects of a dentifrice containing green tea bioflavonoids, sanguinarine or triclosan on oral bacterial biofilm formation. 2000. J Clin Dent 11(2):53-9.
Wu JR, Cheng HJ, Shi JP, et al. β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial. Chin J Integr Med. 2021;10.
Wyatt HR, Ogden LG, Cassic KS, Hoagland EA, McKinnon T, Eich N, Chernyshev V, Wood T, Cuomo J, Hill JO. Successful internet-based lifestyle change program on body weight and markers of metabolic health. 2009. Obesity and Weight Management 5(4):167-73.
Guo X, Xu Y, He H, et al. Effects of a Meal Replacement on Body Composition and Metabolic Parameters among Subjects with Overweight or Obesity. J Obes. 2018;2018:2837367.
Guo X, Xu Y, He H, et al. Visceral fat reduction is positively associated with blood pressure reduction in overweight or obese males but not females: an observational study. Nutr Metab (Lond). 2019;16:44.
Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B. (2012) Grape seed extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. J Agric Food Chem. 2012 Jun 29.
Yilmazer-Musa M, Tucker AM, Frei B. Inhibition of a-amylase and a-glucosidase activity by bioflavonoids: implications for carbohydrate metabolism and type-2 diabetes mellitus. 2010. Society for Free Radical Biology and Medicine Annual Meeting, Orlando, FL.
