Proglucamune

Sometimes daily demands can leave you feeling run down as your immune system works to keep up. Proglucamune can help you maintain vitality, even during times of occasional stress.*

USANA Proglucamune uses the power of USANA InCelligence Technology to support your immune system’s ability to adapt and react to your unique needs. It promotes well-being in two important ways:

  • Supports robust, healthy immune responses*
  • Maintains overall wellness and vitality, even during occasional stress*

The unique formula of USANA Proglucamune combines ancient wisdom with modern science to support your body’s natural defenses.*

Stay Well with a Resilient Immune System

Everyday stressors like poor sleep, pollution, diet, and intense exercise can affect immune health. Healthy habits, key nutrients, and targeted immune-support ingredients may help maintain wellness, vitality, and the body’s natural defenses during occasional stress.*

Many everyday events can periodically place mild stress on your immune system—getting too little sleep, being exposed to excess pollution, eating unhealthy foods, not spending enough time outdoors, getting too little exercise, or even exercising too often or too intensely. Common mild mental or emotional stresses can also compound to impact your immune system.*

Several easy habits can help keep your immunity strong: Wash your hands regularly, live a healthy lifestyle, and eat your fruits and veggies. If you want to take additional steps to preserve daily health and vitality, there are nutritional strategies you can use to help support your immune system*:

  1. Add a multivitamin and mineral supplement to your healthy diet to ensure your body has all the essential vitamins and minerals it needs to support overall health and to produce immune cells.*
  2. Help support healthy function of your immune cells by maintaining healthy membranes with omega-3 fatty acids.*
  3. Maintain a healthy gut barrier with prebiotics (which feed your healthy bacteria) or add additional good bacterial support with a probiotic supplement.*

Take your immune-support regimen a step further with targeted nutrients that can energize your immune cells’ ability to fight back against everyday stresses and support optimal health. USANA Proglucamune is formulated with a unique blend of these targeted nutrients to help support your body’s naturally powerful defenses.*

Prime Your Healthy Immune Cells with Proglucamune

Proglucamune uses beta-glucans and zinc to support immune-cell signaling, priming already healthy immune cells to stay prepared for future challenges without fully activating too soon. This balanced readiness supports a healthy immune response when the body encounters everyday foreign stressors.

The immune system is made up of many biological structures and processes that detect and protect against a wide variety of foreign stressors.*

Your immune cells sense what’s going on in their environment. Then they spring into action when a specific compound or molecule binds to a specific receptor. This action sends a message that a response is needed.

Proglucamune primes already healthy immune cells with zinc and beta-glucans that support cell signaling, helping key immune cells recognize a preparatory signal and stay ready for a future response without becoming fully stimulated. Zinc—an immune-supporting mineral—supports cellular communication and helps amplify the effects of USANA InCelligence Technology, while the beta-glucan blend uses the power of cell signaling to prime already healthy immune cells’ natural protective responses. A separate protein is required to activate the immune response, which helps prevent the immune system from being overworked.*

Imagine that some types of immune cells function like a lock that needs two keys to open. Proglucamune provides the first key when its nutrients bind to a receptor on the cell, signaling it to prepare for action. The second key comes from bacteria, foreign substances, or damaged cells. Once primed, macrophages, neutrophils, and natural killer cells stay ready to respond quickly when that second signal appears, supporting a robust immune response when your body needs it.*

The result is a balanced state of readiness: your body’s protective mechanisms stay prepared to respond quickly without becoming fully active before they’re needed. This readiness helps your body stay fit and healthy.*

A Better Source of Beta-glucans

Proglucamune includes beta-glucans from baker’s yeast and mushrooms to support immune readiness. Its formula blends traditional mushroom use with modern cell-signaling science, using carefully sourced ingredients designed to help maintain wellness, vitality, and immune health.*

The immune-supporting power of Proglucamune comes from zinc plus the unique InCelligence Beta-Glucan Complex. Beta-glucans are naturally occurring polysaccharides—carbohydrate chains of simple sugars—that can come from many sources, including fungi and yeast.*

Most beta-glucan supplements only contain active ingredients from a single source. Proglucamune offers more comprehensive support with beta-glucans from two different sources: mushrooms and baker’s yeast.*

Baker’s Yeast

A number of studies have found that the baker’s yeast in Proglucamune can help maintain wellness in moderately stressed adult men and women. During these studies, maintained respiratory health, vigor, and overall health and energy levels were seen with supplementation. Calmness and mental clarity were also maintained during occasional mild stresses.*

The strain of baker’s yeast in Proglucamune isn’t the common yeast used for baking. It’s been scientifically designed to deliver excellent support for immune health. (This is a beta 1,3/1,6 glucan. The number indicates its structure. Differences in molecular weight or structure determine biological activity.) The beta-glucan in Proglucamune is extracted from the cell wall of a highly purified, organic strain of Saccharomyces cerevisiae (one of the most common species of yeast).*

Clinical studies have shown that this innovative baker’s yeast beta-glucan provides exceptional support for immunity and daily wellness. It appears to be especially beneficial for maintaining respiratory health.*

Mushrooms

Traditional Eastern cultures have used mushrooms for thousands of years to support energy and robust health. Reishi (Ganoderma lucidum) and shiitake (Lentinula edodes) mushrooms have long been used to support wellness and vitality in ancient cultures.

Reishi offers antioxidant activity and is also considered an adaptogen—an herb that helps your body adapt to occasional stress. Traditionally, it’s been used to support balance and calmness.*

Unfortunately, you can’t get the same level of benefits from simply eating your favorite mushrooms every day. The organic, whole-mushroom powders used in Proglucamune begin from genetically pure strains. The mushrooms are grown on brown rice and antioxidant-rich purple corn. This proprietary process helps preserve the naturally occurring active compounds found in mushrooms.*

By supporting the immune system, mushrooms are thought to help support Qi—your so-called circulating life force that is the basis of Eastern philosophy.*

Measuring Qi through Clinical Studies

USANA scientists developed a standardized way to assess Protective Qi, then used clinical studies to evaluate beta-glucan supplementation. Results suggested favorable changes in Protective Qi status, connecting Traditional Chinese Medicine (TCM) concepts with modern research on immune readiness and daily vitality.

Traditional Chinese Medicine (TCM) is a holistic health practice focused on supporting balance in the body through approaches such as herbs, acupuncture, and diet. One important TCM concept is Qi, often described in traditional terms as the body’s vital energy. Protective Qi is traditionally associated with the body’s ability to maintain resilience against everyday external stressors.*

Because Qi is traditionally assessed through observation rather than laboratory testing, it can be difficult to evaluate using conventional research methods. To address this, USANA scientists developed a standardized approach for evaluating Protective Qi and then applied it to clinical research.

The research program progressed in three steps: developing a method for measuring Protective Qi, pilot testing the impact of beta-glucan supplementation on Protective Qi, and evaluating the findings further in a randomized, double-blind, placebo-controlled trial. Together, these studies helped translate a traditional wellness concept into a framework that could be evaluated with evidence-based methods.

  1. Study 1: Researchers identified the ways to measure Protective Qi and developed a reproducible scoring system, creating a standardized method for assessment.*
  2. Study 2: Using this scoring system, researchers conducted a pilot study of beta-glucan supplementation. While the study was small and uncontrolled, results suggested favorable changes in Protective Qi status and supported further investigation.*
  3. Study 3: In a randomized, double-blind, placebo-controlled trial, beta-glucan supported Protective Qi better than the placebo did, based on both traditional evaluations and the standardized assessment tool.*

Results

These studies demonstrated that Protective Qi can be evaluated using a reproducible scoring system and studied through modern clinical research. Findings showed favorable changes in Protective Qi measures with beta-glucan supplementation, helping bridge the traditional TCM concept of Protective Qi with contemporary research on immune readiness and daily vitality.*

Maintain Wellness During Occasional Stress*

Physical and psychological stresses can impact immune function. Proglucamune was formulated with ingredients expressly selected for their ability to maintain robust immune health, even during times of occasional stress.*

Key Ingredients

  • Baker’s Yeast Extract
  • Reishi Mushroom
  • Shiitake Mushroom
  • Zinc

Usage

  • Take two (2) tablets daily, preferably with food.

Ideal For

  • Healthy adults
  • Athletes
  • People under occasional high levels of stress

If you have an autoimmune disease, an immune system disorder, or if you are taking immunosuppressant medication, consult your doctor before using this product. Consult your physician if you are pregnant, nursing, taking a prescription drug, or have a medical condition.

Who can take Proglucamune?

Proglucamune is only intended to be taken by healthy adults, 18 years and older. Proglucamune is not recommended for children unless being taken under the supervision of a medical professional.

Any individual with an autoimmune disorder should consult their doctor before using Proglucamune. USANA has no clinical data to support either the safety or efficacy of Proglucamune in individuals with autoimmune disorders. Additionally, individuals who are taking medications should also consult their physicians prior to use.

Will Proglucamune help if I am already sick?

Proglucamune helps prime immune cells to support a healthy immune system. To do this, the product must be taken continually and already be in your system. It would not be expected to offer any benefit for those who are already sick.*

Can I take Proglucamune if I’m pregnant?

Proglucamune usage should be discussed with a healthcare professional prior to use during pregnancy and lactation. It contains ingredients that lack sufficient safety data for USANA to recommend its general usage during pregnancy.

Why should I take Proglucamune if I already take a product that claims to support immune health?

Proglucamune works via a unique mechanism called priming. Once an immune cell is primed it can better support your body’s natural immune response. Other ingredients work through entirely different mechanisms. Because of the different mechanisms of these ingredients and their potentially positive interactions, adding Proglucamune to these other ingredients may further help support a healthy immune system.*

Should I take Proglucamune if I already use USANA Booster C 600?

Proglucamune can be taken every day, while Booster C 600 is best used in times when your immune system needs additional support.

The active ingredients in Proglucamune include mushroom and yeast extracts, as well as zinc to help support a healthy immune system. It is scientifically designed to be taken every day.*

The active ingredients in Booster C 600 include vitamin C, zinc, black elderberry, and Echinacea. Both Echinacea and elderberry have long been used for their beneficial effects on the immune system. With short-term use, Echinacea has been shown to naturally support a healthy immune system. However, it is recommended that Booster C 600 be used only for short periods, generally two weeks or less.*

What is the difference between consuming the actual ingredients, as compared to taking Proglucamune?

Two major reasons come to mind. First is potency. Yeast and mushrooms tend to be very bulky in size relative to their weight. It would be very difficult to consume enough yeast and mushrooms, consistently, day-after-day, to achieve dosages of beta-glucans shown to have health benefits. Using the concentrated and standardized ingredients found in Proglucamune helps ensure you are achieving the right dosage of beta-glucans to help you support your health.

Junrong W, Haojie c, Jianpin S, et al. Development and validation of a diagnostic risk score for assessing a TCM condition, Protective Qi Deficiency, in adults. Eu J Int Med. 2020;35(101097).

Levy M, Wu JR, Shi JP, et al. Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults. Chin J Integr Med. 2021;27(9):666-673.

Wu JR, Cheng HJ, Shi JP, et al. β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial. Chin J Integr Med. 2021;10.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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