Should I take supplements with a meal?

There are several reasons it can be beneficial to take dietary supplements with food or a complete meal.

One reason is to buffer the stomach (especially important for those with sensitive stomachs).
Another reason is to increase consistency and compliance with the recommended dosage. Many people find it easier to form a habit of taking supplements alongside a meal, as opposed to taking them separately.
Perhaps the best reason to take supplements with a meal is that some nutrients (e.g. fat-soluble nutrients and calcium) typically have improved absorption when taken with a meal or snack.