Hepasil DTX

Nearly everything you consume passes through your liver, making its health essential to everyday wellness. USANA Hepasil DTX supports normal liver function and helps promote your body’s natural detoxification processes.*

Hepasil DTX includes technologies and ingredients that have been evaluated in human clinical research. In a study of healthy adults, researchers reported the following findings:

  • Supporting natural detoxification processes—in a human clinical study, glutathione levels were observed to be 74% higher after 28 days*
  • Sustaining antioxidant capacity—in a human clinical study, overall antioxidant capacity was observed to be 62% higher after 28 days, along with maintenance of vitamin C status*

In addition to supporting your liver function, many of the ingredients in Hepasil DTX also provide antioxidant activity to help protect cells from damaging oxidative stress.*

Hepasil DTX is a powerhouse supplement for liver and detoxification support.*

Why Liver Support Matters

Nearly everything you consume passes through your liver, making it essential to everyday wellness. Healthy lifestyle habits and advanced daily support like USANA Hepasil DTX can help maintain liver function and support your body’s natural detoxification processes.*

After passing through the digestive tract, almost everything you consume—food, drinks, medications, supplements—goes through your liver. Your liver is responsible for filtering everything you consume, breaking down nutrients into forms your body can use, and producing and storing substances your body needs for energy and other functions.

Because the liver is such a hardworking organ, it’s important to keep it healthy by managing daily stressors and adopting beneficial lifestyle habits. Here is a list of practices to help maintain your liver:

  • Limit your alcohol intake: Recommendations are one drink or less per day for women, and two drinks or less per day for men.
  • Eat a healthy diet: Reduce your intake of excess sugar and fatty foods and focus on eating plenty of fruits and vegetables.
  • Use medications safely: Always follow prescriptions and avoid misusing any medications.
  • Minimize toxin exposure: Wear protective equipment when using cleaning and gardening products and try to avoid high amounts of environmental pollution.
  • Maintain a healthy weight: Avoid overeating and get adequate exercise to help maintain a healthy weight.
  • Stay hydrated: Drink enough water throughout the day.
  • Practice good hygiene: Wash your hands and maintain hygiene habits that support overall wellness.

You can also help your liver thrive with advanced daily support. Add USANA’s Hepasil DTX to your healthy lifestyle to help maintain liver function and support your body’s natural detoxification processes.*

How Healthy Detoxification Works

The liver detoxifies harmful compounds through a multi‑phase process supported by antioxidants like glutathione. Hepasil DTX provides nutrients that help maintain balanced detoxification pathways, support antioxidant capacity, and promote healthy glutathione levels for ongoing liver support.*

Many toxic compounds that enter the body, such as alcohol, metabolic byproducts, medications, pollutants, and environmental chemicals, cannot be directly neutralized. Liver detoxification is the process of chemically modifying these toxins so that they can be safely excreted from the body. This detoxification process happens in three phases.

PHASE I

During Phase I, enzymes begin transforming toxins by joining the toxic molecules with other reactive molecules. This is primarily a preparation step to make toxins more recognizable and workable by the body in Phase II detoxification. Unfortunately, this initial oxidation can make some compounds more toxic. However, your body has a second phase of detoxification that kicks in to defuse the situation.*

PHASE II

In the second phase of detoxification, the highly reactive molecules that come out of phase I detoxification are combined with various compounds that neutralize them. These are known as Phase II detoxification enzymes. Glutathione, amino acids, and methyl groups are all included in this process (along with other substances).*

PHASE III

Once the Phase I byproducts are chained to water‑soluble molecules in Phase II, Phase III enables these byproducts to be transported and excreted from the body in bile or urine.*

THE DETOXIFICATION PROCESS

It’s important that the phases of the detoxification processes are balanced properly. You need Phase I enzymes to start the process. Then it’s vital that there are enough Phase II enzymes to ensure the reactive molecules are neutralized to maintain cellular function and support healthy aging.*

The natural detoxification process is dynamic, with a lot of reactions and conversions happening as substances are metabolized. This process can generate a lot of free radicals. Enzymes like glutathione can defend against damaging oxidative stress to maintain the health of your liver cells.*

Glutathione is a master detoxifier. In addition to its action as a Phase II detoxification enzyme, glutathione helps the liver regulate lipid, glucose, and amino acid use by the body. It supports the removal of formaldehyde produced during normal metabolism. It also supports healthy liver cells by acting as an antioxidant.*

Unfortunately, glutathione from food or supplements is inefficiently absorbed. It’s best to give your body what it needs to make it. In addition to having enough protein from your diet, a number of micronutrients can help support this process. That’s where Hepasil DTX comes in. It supplies your body with plenty of nutrients it can use to help keep these natural detoxification reactions in balance.*

The ingredients in Hepasil DTX have been shown to support healthy circulating glutathione levels following supplementation. Research also suggests it may help preserve other antioxidants, including vitamin C. This is notable because Hepasil DTX does not contain vitamin C itself. Vitamin C status has traditionally been associated with direct vitamin C intake, but USANA research show that the antioxidant support offered with Hepasil DTX may help optimize both circulating and tissue vitamin C levels.*

What Makes Hepasil DTX Unique

USANA Hepasil DTX combines exclusive technologies and targeted nutrients to support liver detoxification and metabolism. Ingredients like biotin, choline, and antioxidant‑rich phytonutrients help maintain healthy detox pathways, support glutathione production, and defend cells from oxidative stress.*

Taking a daily supplement like USANA Hepasil DTX can help support your liver’s essential detoxification and metabolic functions. Hepasil DTX is formulated with several technologies exclusive to USANA and designed to work with your body’s natural processes, including:

  • USANA InCelligence Technology, which helps activate key natural detoxification pathways*
  • Olivol, a concentrated olive‑fruit extract developed by USANA scientists and included in the InCelligence Detox‑Support Complex*
  • Nutritional Hybrid Technology, which allows for a unique combination of ingredients delivered at a potency that may not be available in many other products.

Your liver uses many nutrients to drive key parts of the metabolism process. Hepasil DTX is an excellent source of biotin and choline to help ensure you have plenty of both nutrients, so your liver can help keep you energized.*

Biotin

Your liver uses biotin to form metabolic enzymes, substances that cause chemical reactions to break down and change macronutrients, like carbohydrates and protein, into usable compounds. These biotin-dependent enzymes don’t just break nutrients down, they help your liver make substances your body needs for energy, like fatty acids and glycogen (a type of sugar your body uses for fuel).*

Choline

Not only is choline necessary for supporting normal detoxification reactions, but your body also uses choline to mobilize many steps of the metabolic process. One of the most important uses is helping to create phosphatidylcholine (a type of lipid) and betaine (an amino acid). These compounds are vital for helping to move fats and cholesterol out of your liver. This vitamin-like substance is also necessary for supporting normal detoxification reactions.*

Your body can make some choline, but it also needs a steady supply from the diet. Unfortunately, many people don’t eat enough foods with choline (e.g. liver, eggs, fish, chicken, soybeans, mushrooms, etc.). Additional choline could be even more important if you regularly participate in endurance sports (such as triathlons and marathons). Strenuous physical activity has been shown to reduce plasma choline concentrations by about 40 percent.*

Hepasil DTX’s InCelligence Detox Support Complex provides a unique blend of phytonutrients designed to activate key cellsignaling pathways that support your body’s natural detoxification processes. These ingredients help support glutathione production and optimze antioxidant activity, giving your liver the support it needs to stay healthy and resilient.*

This proprietary combination—including milk thistle, green tea, cystine, ALA, Olivol, curcumin, and broccoli concentrate—helps your body produce and maintain essential antioxidants and protective enzymes. Together, they reinforce your liver’s natural defenses and support overall cellular health.*

Milk thistle (Silybum marianum) extract

The extract in Hepasil DTX is derived from the seeds of the milk thistle fruit. Milk thistle is one of the most frequently used herbal extracts for maintaining the health and function of liver cells. It provides a concentrated amount of the active ingredient silymarin. Recent research revealed silymarin’s benefits may come from its ability to help support regulating important cell-signaling pathways for stimulating liver enzymes. It also promotes the production of your body’s natural antioxidants.*

N-acetyl L-cysteine (NAC)

Hepasil DTX supplements the amount of this amino acid naturally made from L-cysteine in your body. It helps your body make its own glutathione (a powerful antioxidant) to maintain healthy levels in the liver.*

Alpha-Lipoic Acid (ALA)

Alpha-lipoic acid, which is also naturally produced in the body, helps your body make glutathione, offers direct antioxidant activity, and helps recycle other antioxidants, including vitamins C and E.*

Historically, ALA could not be combined with cystine as the two ingredients would break down and lose potency quickly. Because they’re combined using USANA Nutritional Hybrid Technology, these two powerful nutrients can be kept separate to retain potency but still be delivered in one tablet.

Broccoli (Brassica oleracea) extract

The broccoli concentrate in Hepasil DTX comes from cruciferous vegetables, studied for their beneficial effects on cell-signaling pathways. Cruciferous vegetables contain glucoraphanin, which the body can convert into sulforaphane—a well‑studied antioxidant molecule. These compounds help activate important natural pathways that support your body’s natural detoxification enzymes.*

Inositol

Inositol is a vitamin-like substance that’s closely related to glucose in structure. While it is most abundant in the brain, spinal cord, and spinal fluid, this naturally occurring carbohydrate also helps support the metabolism of fats.*

Green-tea (Camellia sinensis) extract

With 90 percent polyphenols, the green tea extract in Hepasil DTX offers concentrated antioxidant activity. One of the most studied antioxidant compounds in green tea is epigallocatechin‐3‐gallate (EGCG). This compound has been shown to help support important cell-signaling pathways.*

Olivol olive-fruit (Olea europaea) extract

USANA scientists developed Olivol extract to deliver the potent antioxidant benefits of olive oil in a unique ingredient. The olive-fruit extract helps defend cells from oxidative damage. Research has indicated that hydroxytyrosol, one of the active phenolic compounds in olives, also helps the body produce its own protective antioxidant enzymes.*

Meriva Bioavailable Curcumin Extract

Meriva is the source of another nutrient you’ve probably heard a lot about: curcumin. The “golden spice of India” has been used for thousands of years as part of Ayurveda (an ancient approach to holistic wellness). More recently, it has garnered a lot of attention. Studies have revealed that curcumin provides many benefits for health, including maintaining antioxidant activity and supporting healthy immune responses. Curcumin has also been shown to influence the production of your body’s own antioxidants and help retain normal levels of key detoxification enzymes.*

Evidence From Clinical Research

Human clinical research shows Hepasil DTX supports antioxidant and natural detoxification capacity by optimizing glutathione and vitamin C levels, supporting Phase II natural detoxification enzyme activity, and maintaining overall antioxidant reserve in healthy adults.

A study was conducted to evaluate the efficacy of Hepasil DTX to better understand how its targeted formulation supports natural liver detoxification and antioxidant capacity. Key findings from human research included examining changes in glutathione levels, vitamin C status, detoxification enzyme activity, and overall antioxidant reserve.*

The study was published and presented as scientific research posters:

Researchers designed a double-blind placebo-controlled study with 15 healthy adults and took place over three phases: acute (first 0-8 hours after dose), chronic (28 days), acute-on-chronic (0-8 hours after dose on day 28).*

STUDY CONCLUSIONS

At the end of the study, participants showed the following results:

  • Glutathione levels increased significantly at 8 hours during the Acute Phase and again on the acute-on-chronic phase. Overall, GSH rose 74% over the full study.*
  • Vitamin C levels showed a significant rise within 2 hours after the first dose and maintained during the acute phase. They increased again in the acute-on-chronic phase.*
  • Activity from Glutathione S‑transferase (GST)—a family of Phase II detoxification enzymes—increased significantly at 8 hours (acute) and at 4 and 8 hours (acute‑on‑chronic).*
  • Serum Antioxidant Reserve (SAR)—a measure of the body’s overall capacity to neutralize free radicals and defend against oxidative stress—increased 32% within two hours of the first dose and rose 62% by day 28, with further significant increases during the acute‑on‑chronic phase.*

The results of this data suggest that Hepasil DTX supports optimized natural detoxification capacity by sustaining glutathione levels, vitamin C status, GST activity, and overall antioxidant reserve. The research reinforces the formulation strategy behind Hepasil DTX: supporting balanced Phase I, Phase II, and Phase III natural detoxification pathways while helping maintain antioxidant defenses over time. Individual results may vary. By working with the body’s natural processes, Hepasil DTX helps provide meaningful, ongoing support for healthy liver function and everyday wellness.*

Practical Benefits of Hepasil DTX

Support your liver by helping protect your cells from oxidative stress. The optimized antioxidant capacity of Hepasil DTX promotes liver efficiency, helping the liver perform its essential roles in metabolism and natural detoxification.*

Key Ingredients

  • InCelligence Detox-Support Complex
    • Milk thistle extract
    • N-acetyl L-cysteine (NAC)
    • Alpha lipoic acid (ALA)
    • Curcumin

Usage

  • Adults take three (3) tablets daily, preferably with food.

Ideal For

  • Healthy adults
  • Endurance athletes
  • People exposed to pollution or toxins

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Frequently Asked Questions

A. Supporting healthy liver function is always a good idea. But it’s especially important when your body is exposed to increased pollution or when you consume less healthy food and drink. If you know you’re going to need some extra support, it’s best to take Hepasil DTX before the exposure, not after. This will help ensure your liver has the support it needs to keep up with the extra load when it needs it.*

A. Hepasil DTX contains a unique blend of ingredients that support cell signaling pathways tied to glutathione production. This process sustains both the body’s antioxidant and natural detoxification capacity by increasing plasma glutathione and vitamin C levels.*

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