Hepasil DTX™: What You Need to Know
Hepasil DTX™ is a carefully formulated blend of antioxidants aimed at supporting and maintaining your body’s second largest organ: the liver.
The main ingredient is milk thistle extract—one of the most powerful currently known antioxidants. Milk thistle helps increase the amount and activity of several antioxidant enzymes involved in detoxification (including superoxide dismutase (SOD) and the glutathione peroxidase system).
Other important antioxidants in Hepasil DTX include alpha-lipoic acid, green tea extract, turmeric extract, and Olivol® patented olive-fruit extract. Each helps protect multiple enzyme systems in the liver, and provides secondary antioxidant protection to the rest of the body.
Adding a supplement like USANA’s Hepasil DTX—with the unique InCelligence Detox-Support Complex™—to your healthy lifestyle is a great way to help maintain healthy liver function. You can also help support your body’s natural detoxification processes.*
- The liver is the major detoxifying organ in the body.
- Glutathione—a powerful antioxidant made in the body—and vitamin C are involved in the detoxification pathways.
- Milk thistle extract supports liver-cell health and scavenges free radicals.*
- N-acetyl l-cysteine is a precursor to glutathione.*
- Alpha-lipoic acid influences the production of glutathione and it supports Phase II detoxification reactions.*
- Patented Olivol® olive-fruit extract, broccoli extract, green tea extract, and turmeric provide excellent antioxidant support. This is crucial for liver health because the detoxification process generates a lot of damaging free radicals.*
- Adding USANA’s Hepasil DTX to a healthy lifestyle can help maintain healthy liver function and balance the body’s natural detoxification processes.*
The Benefits of Hepasil DTX™
Your liver is vital to maintaining good health. Almost every nutrient you consume—food, drinks, medications, and supplements—goes through your liver. That’s where the nutrients are broken down into a form your body can use, or altered and eliminated from your system.*
Hepasil DTX is enhanced with USANA InCelligence Technology® to support healthy liver function in many ways. It supplies the body with nutrients that promote the natural detoxification process and endogenous antioxidant activity.*
The Anatomy and Physiology of the Liver
The liver is the major detoxifying organ in the body and the primary site of Phase I and Phase II detoxification enzymes. It’s located in the upper right area of the abdomen.
Your liver performs multiple functions important to keeping you alive and well. It helps convert nutrients from your diet into substances your body can use. The liver plays an important role in turning toxic substances in your body into harmless substances or expelling them.
These toxic substances go through the Phase I and Phase II detoxification process.
Phase I detoxification enzymes consist of the cytochrome P450 family of enzymes. These serve as the first line of defense, neutralizing most toxins. Unfortunately, this initial oxidation can occasionally make some compounds more toxic. Phase II detoxification enzymes can further modify the products of Phase I by chaining them to water-soluble molecules. Now they are less toxic and able to be passed from the body.
These detoxification pathways are aided by the antioxidant activity of vitamin C and glutathione—a powerful antioxidant enzyme made in your body.
Glutathione is the most abundant antioxidant in our bodies and plays a major role in the detoxification process. Unfortunately, glutathione is inefficiently absorbed from the diet and must be manufactured in the body by specific Phase II enzymes.
Under normal conditions, these enzymes produce low levels of glutathione. But when your body encounters more toxins it increases production of glutathione by upregulating the Phase II enzymes. A number of phytochemicals, including broccoli extract, milk thistle, and alpha-lipoic acid, have also been shown to upregulate Phase II enzymes, including those that synthesize glutathione.
Vitamin C is an important first line of defense in protecting biomolecules from oxidative damage, especially in circulation.
However, the concentration of vitamin C in the body is tightly regulated by intestinal absorption from the diet and recycling by the kidneys. Because of this tight regulation, it was thought that circulating vitamin C levels could only be increased by supplementing with vitamin C. However, it has recently been shown that both circulating and tissue levels of vitamin C can be increased by certain phytochemicals, even in the absence of vitamin C supplementation.
Milk Thistle Extract
Milk thistle’s active ingredient, the one that supports the liver, is called silymarin. This is a chemical extract from milk thistle seeds. Silymarin is a strong antioxidant.
The Science Behind Hepasil DTX™
Choline is a key ingredient that helps the liver metabolize fats and cholesterol and move them out of the liver. Upon entry into the cell, choline is oxidized to become betaine, which donates methyl groups necessary for healthy detoxification reactions.
The liver uses biotin to support the metabolism of macronutrients and the synthesis of glycogen for energy.
In addition to alpha-lipoic acid and n-acetyl l-cysteine, the InCelligence Detox-Support Complex in Hepasil DTX also delivers a comprehensive array of phytochemicals. This includes green-tea extract, milk thistle extract, broccoli extract, and USANA’s patented Olivol®.
These powerful nutrients target a cell-signaling pathway that supports naturally protective processes within a healthy liver:
- Balancing detoxification reactions by stimulating the production of Phase II detoxification enzymes, including glutathione-S-transferases. These enzymes link with the highly reactive metabolites—products of a metabolic reaction—generated in the liver during Phase I and convert them into a form that can be excreted from the body.
- Defending against oxidative stress caused by free radicals generated during Phase I by acting as direct antioxidants. The nutrients also activate the production of endogenous antioxidants—those made in the body—including glutathione, which is most concentrated in the liver.
Taking three tablets of Hepasil DTX a day for 28 days can help significantly optimize natural glutathione production and overall antioxidant capacity. The formula is patent pending because of the increase in glutathione, vitamin C antioxidant capacity, and detoxification activity it helps produce within the body.*
How Does Hepasil DTX Affect Cell Signaling?
Hepasil DTX contains a unique blend of ingredients that optimize cell-signaling pathways tied with glutathione production. This process both supports the body’s antioxidant and natural detoxification capacity by increasing plasma glutathione and vitamin C levels.
USANA’s in-house scientists have conducted a double-blind controlled study to test the effectiveness of Hepasil DTX.
The study’s results showed that both circulating glutathione and vitamin C levels increased following treatments with Hepasil DTX. To our knowledge, this is the first time a combination of essential nutrients and phytochemicals have been shown to increase both plasma vitamin C and glutathione levels simultaneously. The results also showed that the recommended dosage of Hepasil DTX is able to boost both glutathione and vitamin C levels—essential molecules for antioxidant defense and to support the natural detoxification pathways and process.
The study looked at whole blood glutathione (GSH) and vitamin C levels. The purpose was to assess the effectiveness of Hepasil DTX in increasing both GSH and vitamin C levels. Results showed that Hepasil DTX significantly increased plasma GSH just eight hours after supplementation during the Acute-on-Chronic Phase. It also increased plasma vitamin C levels as soon as two hours following the first treatment, and this was maintained during the entire Acute Phase.
To show the observed increases in glutathione and vitamin C translate into a clinical benefit, USANA scientists went on to determine the antioxidant capacity of each subject’s blood. They utilized the serum antioxidant reserve (SAR) assay developed by USANA Health Sciences to find that subjects that supplemented with Hepasil DTX were significantly more resistant to oxidative damage than subjects given the placebo.
This proprietary combination of essential nutrients and broccoli extract, milk thistle, and alpha-lipoic acid increases plasma vitamin C and glutathione levels simultaneously, and turns on the molecular machinery needed to utilize glutathione in the detoxification reactions. It also significantly increases the overall capacity of the blood to protect against oxidative insult.
Together, these results show that taking the recommended dose of Hepasil DTX increased antioxidant capacities and the body’s natural detoxification capacities by boosting glutathione and vitamin C levels.*
The USANA Difference
Hepasil DTX™ has two patents pending. The first is for the formula’s effectiveness. Another for safely combining previously incompatible, but equally important, nutrients into one bi-layer tablet using USANA’s Nutritional Hybrid Technology.
This technology enables USANA to manufacture a truly unique, comprehensive liver support supplement. And the InCelligence Detox-Support Complex unlocks the innate intelligence of your body’s natural processes to help support the longevity of your liver.*
Frequently Asked Questions
What is Hepasil DTX?
Hepasil DTX is a carefully formulated blend of antioxidants aimed at supporting and maintaining the body’s second largest organ: the liver.
The main ingredient in Hepasil DTX is Milk Thistle Extract. It is one of the most powerful antioxidants currently known, and it helps to increase both the amount and the activity of several antioxidant enzyme systems involved in the detoxification process (including superoxide dismutase (SOD) and the glutathione peroxidase system).
Other important antioxidants in Hepasil DTX include alpha-lipoic acid, green tea extract, turmeric extract, and the patented olive fruit extract Olivol. Each of these helps to protect multiple enzyme systems in the liver, as well as providing secondary antioxidant protection to the rest of the body.
Additional key ingredients in Hepasil include choline (a precursor to betaine and a methyl-group donor in detoxification reactions), n-acetyl L-cysteine (a precursor to glutathione), and biotin (a key component of fatty acid synthesis).
How Does Hepasil DTX Affect Cell Signaling?
Hepasil DTX contains a unique blend of ingredients that alter cell signaling pathways tied with glutathione production. This process increases both the body’s antioxidant and detoxification capacity, by increasing plasma glutathione and vitamin C levels.
What Changed in InCelligence Versions of Procosa and Hepasil?
It has always been clear to USANA scientists that some nutrients have a positive impact on the cell signalling pathways of the human body. With this in mind, USANA scientists used this knowledge to design the most recent Hepasil and Procosa formulations. Although the reformulation of these products occurred a few years ago, the branding of the products has been updated to highlight a technology that was already being utilized.
Which Products Currently Use Nutritional Hybrid Technology?
The USANA products that currently use Nutritional Hybrid Technology include:
- Proflavanol C100
- Proflavanol C200
- Hepasil DTX
- *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Gazak R, Walterova D, Kren V. Silybin and Silymarin – New and Emerging Applications in Medicine. 2007. Current Medicinal Chemistry 14(3):315-38.
- Jiao HL, Ye P, Zhao BL. Protective effects of green tea polyphenols on human HepG2 cells against oxidative damage of feno brate. 2003. Free Radic Biol Med 35(9):1121-8.
- Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. 1996. Carcinogenesis 17(4):793-9.
- Lang I, Deak G, Muzes G, Pronai L, Feher J. Effect of the natural bio avonoid antioxidant silymarin on superoxide dismutase (SOD) activity and expression in vitro. 1993. Biotechnol Ther 4(3-4):263-70.
- Manna C, Galletti P, Cucciolla V, Montedoro G, Zappia V. Olive oil hydroxytyrosol protects human erythrocytes against oxidative damages. 1999. J Nutr Biochem 10(3):159-65.
- Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. 1999. J Immunol 163(12):6800-9.
- Sreejayan, Rao MN. Curcuminoids as potent inhibitors of lipid peroxidation. 1994. J Pharm Pharmacol. 46(12):1013-6.
- Wellington K, Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. 2001. BioDrugs 15(7):465-89.
- Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA, Willett WC. Dietary choline and betaine assessed by food- frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. 2006. AJCN 83(4):905-11.