Dong quai (Angelica sinensis) is a member of the celery family. The plant is typically found growing in damp mountain ravines, riverbanks, meadows, and coastal areas. Its greenish-white flowers bloom from May to August.

For centuries, Dong quai has been used in traditional Chinese medicine to alleviate gynecological complaints, including dysmenorrhea (painful menstruation) and amenorrhea (lack of menstruation). It has also been used as a uterine smooth muscle relaxant and for alleviating menopausal symptoms (like hot flashes and vaginal dryness). It has been called the “ultimate herb” for women, and it is commonly found in many mixed herbal products developed specifically for use by women.
Dong quai is not recommended for use during pregnancy and lactation.

Mitochondria, a membrane-enclosed cellular organelles, which produce energy, 3D illustration

Coenzyme Q10 (ubiquinone, ubidecarenone, CoQ10) molecule, chemical structure. Plays an essential role in the production of cellular energy; has antioxidant properties. Chalk on blackboard style illustration.

Your body doesn’t have to look very far to find Coenzyme Q10. It’s in almost every one of your cells. Maybe that’s why it belongs to a category of molecules called ubiquinones (ubiquitous meaning everywhere). This widespread distribution in your body also means CoQ10 benefits abound.

Q10 is important to prepare cellular reactions (that’s what a coenzyme does). It helps cells produce energy for growth and maintenance. CoQ10 also works as an antioxidant that protects you from the same energy-making process it’s also involved in.

But you can’t rely on your natural production forever. It falls off the older you get. So, Q10 is what’s called a conditionally essential nutrient—required under certain circumstances. In this case, age.

Maintaining optimal Coenzyme Q10 levels is important. Discover how CoQ10 works, how it benefits your health, and where you can find it in your diet.

Vitamin Q? Not Quite

If it works like a vitamin, looks like a vitamin, and acts like a vitamin, then it’s a vitamin. Or is it?

CoQ10 doesn’t quite check off the final box. Vitamins are compounds that have to come from your diet or supplementation because you need them and can’t make them. Coenzyme Q10 is not quite an essential substance because your body can make quite a bit of it. At least for some of your life.

Age takes its toll on CoQ10 production. As you get older, your natural production of Coenzyme Q10 falls off. But your need for it never does. So, you could say that Q10 is conditionally essential—especially for older people and those dealing with specific health concerns. That makes it about as close to a vitamin as a non-vitamin can get.

The lack of a full vitamin designation doesn’t make it any less important for optimal health. Let’s look at some of the functions of CoQ10.

CoenzymeQ10 Loves Electrons

First—and this is a bit obvious given the name—CoQ10 works as a coenzyme. That’s how most vitamins work in your body. They help spark reactions in your cells. After all, your cells are basically just bags of chemical reactions. Coenzyme Q10—like it’s vitamin doppelgangers—assists important reactions that help your body run smoothly.

Coenzyme Q10 has the same solubility requirements as vitamin A, D, E, and K. All those compounds require fat for absorption into your body. This is because they all have tails hanging off of the key part of the molecule that look like fats themselves. This is where “Q10” part of the name comes from. This tail is 10 carbon atoms long in humans. In other mammals, for example, this tail is nine carbons long and takes the name Coenzyme Q9.

Q10 most closely resembles vitamin K. They have a similar molecular structure. And the both have the same core function to facilitate so-called redox reactions in your body. That means they donate and receive electrons.

Cellular Energy Production and Q10

Mitochondria, a membrane-enclosed cellular organelles, which produce energy, 3D illustration

You’ve probably heard that mitochondria are the powerhouses within your body’s cells. That’s because they’re the site where ATP (adenosine triphosphate), your cells’ energy transporter, is generated. This is done through a process called the electron transport chain.

The mitochondria break apart the chemical bonds in the food you eat. As these bonds break, they release electrons. There are special molecules that capture these electrons and bring them to the electron transport chain in the membrane of the mitochondria. The electron transport chain is a series of protein complexes. As the electrons are shuttled through the transport chain, they’re harnessed for their energy. But for an electron to get through all the protein complexes in the chain, it takes special molecules to shuttle them.

As the electrons are shuttled down the chain, protons are picked up along the way and passed through the mitochondrial membrane. This creates a charge gradient, or potential energy, to drive the enzyme that makes ATP. You can think of the charge gradient as being water behind a dam. As the water (protons) move through the dam (mitochondrial membrane) this potential energy is utilized to power the conversion of ADP, into your body’s cellular energy, ATP.

Let’s translate this into something more familiar. ATP is the energy your cells use to function, much like the gasoline you put into your car for it to run. Using this analogy, you could imagine that Coenzyme Q10 is similar to the pump that gets the gas into your car’s tank. While it’s not the fuel itself, it plays a major role in getting that fuel to your cells in a form they can utilize.

CoQ10: A Quality Antioxidant

The fact that Coenzyme Q10 is a ubiquitous molecule found everywhere in your body is great news! Because it can operate as a powerful antioxidant. And almost by definition, any molecule in your body whose job it is to give and take electrons can also act like an antioxidant.

Extra CoQ10 in your body—those molecules not involved in energy production—is shuttled off to provide antioxidant protection in various membranes in your body.

It works like any other antioxidant to combat oxidation in your body. Coenzyme Q10 neutralizes free radicals by taking on electrons or giving them away. (Similar to its electron transporter role in energy production.) This helps balance these highly reactive byproducts of different processes.

These oxidized molecules with unpaired electrons are called free radicals. They have an odd number of electrons, making them unstable. Without an antioxidant to help free radicals get an even number of electrons, these reactive molecules build up. This increases oxidative stress. As free radicals build up they start reacting with other molecules or structures within the cell. Left unchecked overtime, oxidative stress damages your cells, DNA, proteins, and lipids. This is known as oxidative damage and is detrimental to your health.

Coenzyme Q10 is one of the important antioxidants that helps protect your cells and body structures. Making sure you have adequate levels of CoQ10 helps support a proper balance between free radicals and antioxidants (yep, your body actually needs some free radicals to remain in a healthy balance). This is especially important as you age, because both oxidative stress and oxidative damage is more common as the years stack up. And at the same time, your body produces less Coenzyme Q10.

Other Body Benefits of CoQ10

Q10 is found everywhere in your body, so it supports total body health, usually as an antioxidant. But it can be found in the highest concentration in some of your hardest working organs—the heart, liver, kidneys, and pancreas. These are also the organs that have the most metabolism and energy needs.

There’s been research showing a connection between Coenzyme Q10 and optimal heart health. It’s been successfully used to help people maintain their heart health. CoQ10 supports healthy muscle function, and your largest organ—the skin. It also plays a role in healthy cell growth and maintenance. Coenzyme Q10’s ability to shuttle electrons helps stimulate cell growth and provide sufficient amounts of energy.

How to Increase CoenzymeQ10 in Your Diet

As mentioned before, your body loses its ability to hold onto optimal levels of CoQ10 as you age. Supplementation and strategic meal planning can help combat this decline. Consider the following ideas to increase the amount of Q10 in your diet, so your tank isn’t running on empty:

  • Coenzyme Q10 is often found in fatty cold-water fish. That’s because CoQ10 is fat-soluble. Next time you’re in the market for seafood, choose a fat-rich cut of fish, like tuna, salmon, herring, or mackerel. The American Heart Association recommends eating 3.5 ounces of cooked fatty fish at least twice a week. Not only will this new staple provide you with a boost in Q10, but it also delivers heart-healthy omega-3 fatty acids.
  • Don’t assume that Coenzyme Q10 is only found in sea-based protein. You can also find healthy helpings of the nutrient in beef and even chicken. But beef delivers twice as much as poultry in the same serving size.
  • Various nuts and seeds also provide decent amounts of Coenzyme Q10. While they don’t yield as much as the fatty fish and beef, the amount nuts deliver isn’t negligible. Consider packing nuts as a mid-day work snack. Add sesame seeds or pistachios to a green salad for an extra nutrient kick.
  • Soybean and canola oils, among a few other plant-based oils, provide a satisfactory amount of Q10. Consider swapping these out for your go-to oil occasionally to give your system a CoQ10 boost.

 

Bioflavonoids comprise a diverse class of compounds with antioxidant activity. They are found naturally in the leaves, bark, roots, flowers, and seeds of plants.

Hesperidin is a flavonoid found in the pith of unripe citrus fruits. Chemically, it is a complex of glucose and rhamnose with the flavonone hesperin. At one time it was called vitamin P, since it affects the fragility of capillary walls. (However, it is not technically a vitamin.)

Rutin belongs to a class of water-soluble plant pigments called flavonoids. It is the disaccharide derivative of quercetin, containing glucose and rhamnose. Rutin can be found in grains, tomato stalks, and elderberry blossoms. A variety of evidence indicates that rutin possesses strong antioxidant properties.

Quercetin belongs to a class of water-soluble plant pigments called flavonoids. A variety of evidence indicates that quercetin also possesses strong antioxidant properties.

The antioxidant activities of bioflavonoids complement, extend, and sometimes synergize the antioxidant activities of vitamin C, vitamin E, and carotenoids. As such, bioflavonoids represent an important nutritional component in the body’s defenses against free radical damage.

Cinnamon extract contains bioflavonoids (called proanthocyanidins) similar to the proanthocyanidins contained in grape seeds. The primary type of antioxidant contained in pomegranates is somewhat different from other compounds in USANA’s bioflavonoid complex; as such, it adds to the overall biodiversity of the complex.

Choline is a dietary nutrient necessary for cell membrane integrity and facilitating the movement of fats into and out of cells. Choline is also a precursor for acetylcholine, an important neurotransmitter in the brain. Choline also works with folic acid, vitamin B12, and methionine in methyl group metabolism and maintenance of healthy homocysteine levels. Since high levels of homocysteine increase the risk of cardiovascular disease, an adequate intake of choline may be important in reducing risk.

Pregnancy and lactation are periods when maternal reserves of choline risk becoming depleted. Because the availability of choline for normal fetal development of the brain is critical, expectant and nursing mothers should make certain their choline intake is adequate.

Although choline can be found in a wide variety of foods, some of the richest sources are foods high in cholesterol and fat (e.g. beef liver). Because many Americans have been advised to decrease their consumption of fatty foods, choline intake in some population groups may be inadequate. Healthy sources of choline include Brussel sprouts, broccoli, eggs, lean beef, milk, peanuts, and certain seafoods (shrimp, salmon, and cod).

Bromelain is a general name for a family of sulfhydryl proteolytic enzymes (enzymes capable of digesting protein) obtained from the stem of the pineapple plant. Studies (in animals and in vitro) have demonstrated potential anti-tumor, anti-inflammatory, anti-thrombotic and fibrinolyticactivities. Additional research is underway to investigate the in vivo impact of these effects in humans.

Indole-3-carbinol and isothiocyanates are sulfur-containing chemicals found in cruciferous (cabbage family) vegetables. These compounds are formed from parent compounds when cruciferous vegetables are crushed or cooked. Both are antioxidants, and both are believed to stimulate natural detoxifying enzymes in the body. Emerging research shows good evidence for these compounds being at least partially responsible for the lowered risk of cancer associated with consumption of broccoli and other cruciferous vegetables.

Dietary sources of indole-3-carbinol and isothiocyanates include broccoli, cabbage, cauliflower, kale, and Brussels sprouts.

Black cohosh is a member of the Ranunculaceae (buttercup) plant family native to the eastern deciduous forests of North America. Black cohosh contains several ingredients, including isoflavones (e.g., formononetin) and triterpene glycosides (e.g., acetin and 27-deoxyactein). Other constituents include aromatic acids, tannins, resins, and fatty acids.

Black cohosh is one of the best-known and researched herbs for use with menopausal symptoms. In Germany, where is has been studied and used in clinical research for about forty years, it is prescribed to treat premenstrual syndrome (PMS) and difficult or painful menstruation. It is also effective in relieving many of the uncomfortable symptoms associated with menopause, including hot flashes, depression, and irritability.

Black cohosh has traditionally been used for long periods of time without evidence of adverse effects, and it is tolerated very well when used as intended. However, ingesting extremely high doses of black cohosh may cause gastrointestinal disturbances.

Black cohosh is not recommended for use during pregnancy because of its ability to stimulate uterine contractions.

Bioflavonoids comprise a diverse class of polyphenolic compounds with antioxidant activity. They are found naturally in the leaves, bark, roots, flowers, and seeds of plants.

There are thousands of naturally occurring bioflavonoids, so to aid in classification they have been divided into eight major groups: flavonols, flavones, flavonones, isoflavones, catechins, anthocyanidins, dihydroflavonols, and chalcones. Several of these groups have received attention in the field of human nutrition, including the proanthocyanidins in grape seeds, the flavanones in citrus (e.g. hesperidin), the flavonols in onions and other vegetables (e.g. quercetin), the catechins in green tea, the anthocyanosides in bilberry, and the isoflavones in soybeans.

At present, many of the therapeutic effects of bioflavonoids appear to result from potent antioxidant and free-radical-scavenging properties.

The bilberry fruit (Vaccinium myrtillus) is rich in antioxidant anthocyanosides, vitamin A, and vitamin C. Bilberry has been shown to help maintain healthy capillaries, including those in the eye. While the specific mechanisms behind bilberry’s beneficial effect on the eye are not completely understood, it is thought that the anthocyanosides it provides help improve oxygenation and blood delivery to the eye, act as free radical scavengers, and support the maintenance of healthy capillaries. In addition, these anthocyanosides are thought to have an affinity for the retinal pigment epithelium (RPE), which delivers nutrients to the eye’s photoreceptor cells.

Preliminary human trials conducted in Europe show that bilberry may help to prevent cataracts, and may provide benefits for people with mildretinopathies (such as macular degeneration and diabetic retinopathy).