Nrf2-Mediated Antioxidant Protection by Nutritional Supplementation May be an Effective Strategy in the Progression of Age-Related Macular Degeneration
It is well established that nutrients such as lutein, zeaxanthin and zinc among others are very important for eye health and to protect the macula of the eye. Research conducted by USANA and the University of Texas Medical Branch indicates that Nrf2-mediated antioxidant protection is an important factor in the prevention of age-related macular degeneration (AMD).
Retinal pigment epithelium (RPE) provides important support and protection to the outer retina and vasculature of the eye. Degeneration of RPE is an early step in the initiation and progression of age-related macular degeneration, a leading cause of blindness in adults.
In a series of experiments, it was determined that ingredients in USANA’s InCelligence complex are potent inducers of Nrf2 activity. The activation of this endogenous antioxidant system resulted in support and maintenance of the functions of the RPE, particularly in advanced age, and showed that Nrf2-mediated antioxidant protection by nutritional supplementation may be an effective strategy in the prevention and progression of AMD.
Presented by Jeremy Tian at the World Congress on ‘Redox Medicine and Nutrition’. University of California at Davis May 4 to 6, 2016.